Differential Effects of Aromatic Residues on Amyloid Formation and Cytotoxicity of Human IAPP.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00267
Abstract: Islet amyloid polypeptide (IAPP) is a 37-residue polypeptide hormone secreted by the pancreatic β-cells. IAPP plays a role in glycemic regulation, but in the pre-type-2 diabetic state, it aggregates to form an islet amyloid. The… read more here.
Keywords: amyloid formation; aromatic residues; role; formation cytotoxicity ... See more keywords
Nonhuman IAPP Variants Inhibit Human IAPP Aggregation.
Sign Up to like & getrecommendations! Published in 2021 at "Protein and peptide letters"
DOI: 10.2174/0929866528666210806152706
Abstract: AIM To identify naturally occurring variants of IAPP capable of inhibiting the aggregation of human IAPP and protecting living cells from the toxic effects of human IAPP. BACKGROUND The loss of insulin-producing β-cells and the… read more here.
Keywords: aggregation; iapp variants; capable inhibiting; iapp aggregation ... See more keywords
2189-P: Human IAPP Destabilizes IRF1 Protein to Reduce PD-L1 Expression in INS1 Cells
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-2189-p
Abstract: Background: Programmed death-ligand 1 (PD-L1) plays a critical role to protect β-cells against immune attack. Interferon regulatory factor 1 (IRF1) is a key transcriptional factor to regulate PD-L1 expression, which is induced by various cytokines… read more here.
Keywords: expression; none; human iapp; hiapp ... See more keywords