Differential Effects of Aromatic Residues on Amyloid Formation and Cytotoxicity of Human IAPP.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00267
Abstract: Islet amyloid polypeptide (IAPP) is a 37-residue polypeptide hormone secreted by the pancreatic β-cells. IAPP plays a role in glycemic regulation, but in the pre-type-2 diabetic state, it aggregates to form an islet amyloid. The… read more here.
Keywords: amyloid formation; aromatic residues; role; formation cytotoxicity ... See more keywords
The Structure of Human IAPP Fibrils Reflects Membrane and pH Conditions
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.5c06971
Abstract: Physiologically relevant in vitro models of amyloid aggregation are essential for linking structural insights to disease pathology. In type 2 diabetes, aggregation of human islet amyloid polypeptide (hIAPP) into fibrils is a hallmark of β-cell… read more here.
Keywords: human iapp; hiapp fibrils; hiapp; structure ... See more keywords
Nonhuman IAPP Variants Inhibit Human IAPP Aggregation.
Sign Up to like & getrecommendations! Published in 2021 at "Protein and peptide letters"
DOI: 10.2174/0929866528666210806152706
Abstract: AIM To identify naturally occurring variants of IAPP capable of inhibiting the aggregation of human IAPP and protecting living cells from the toxic effects of human IAPP. BACKGROUND The loss of insulin-producing β-cells and the… read more here.
Keywords: aggregation; iapp variants; capable inhibiting; iapp aggregation ... See more keywords
2189-P: Human IAPP Destabilizes IRF1 Protein to Reduce PD-L1 Expression in INS1 Cells
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-2189-p
Abstract: Background: Programmed death-ligand 1 (PD-L1) plays a critical role to protect β-cells against immune attack. Interferon regulatory factor 1 (IRF1) is a key transcriptional factor to regulate PD-L1 expression, which is induced by various cytokines… read more here.
Keywords: expression; none; human iapp; hiapp ... See more keywords