A novel mouse strain optimized for chronic human antibody administration
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123002119
Abstract: Significance Species differences in IgG Fc–Fcγ receptor (FcγR) interactions have made humanized mouse models an attractive strategy to evaluate the efficacy and toxicity of human antibodies. We previously published a humanized FcγR mouse model that… read more here.
Keywords: human igg; administration; mouse strain; mouse ... See more keywords
Characterization of the interactions of rabbit neonatal Fc receptor (FcRn) with rabbit and human IgG isotypes
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0185662
Abstract: Despite the increasing importance of rabbit as an animal model in pharmacological studies like investigating placental transfer of therapeutic IgGs, little is known about the molecular interaction of the rabbit neonatal Fc receptor (FcRn) with… read more here.
Keywords: human igg; fcrn rabbit; rabbit human; igg isotypes ... See more keywords