Characterization of Human IgG1 Fc Region Stability and Aggregation Propensity
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2663
Abstract: Monoclonal therapeutic antibodies (MAb) are highly valued for their efficacy in treating ailments ranging from arthritis to cancer. Unrivaled specificity and infrequent adverse effects benefit patients in ways traditional small molecule therapeutics cannot. However, formation… read more here.
Keywords: aggregation propensity; stability; human igg1; region ... See more keywords
Antigen-Induced Allosteric Changes in a Human IgG1 Fc Increase Low-Affinity Fcγ Receptor Binding.
Sign Up to like & getrecommendations! Published in 2020 at "Structure"
DOI: 10.1016/j.str.2020.03.001
Abstract: Antibody structure couples adaptive and innate immunity via Fab (antigen binding) and Fc (effector) domains that are connected by unique hinge regions. Because antibodies harbor two or more Fab domains, they are capable of crosslinking… read more here.
Keywords: induced allosteric; low affinity; antigen; antigen induced ... See more keywords
A recombinant human IgG1 Fc multimer designed to mimic the active fraction of IVIG in autoimmunity.
Sign Up to like & getrecommendations! Published in 2019 at "JCI insight"
DOI: 10.1172/jci.insight.121905
Abstract: The antiinflammatory effects of i.v. Ig (IVIG) in the treatment of autoimmune disease are due, in part, to the Fc fragments of Ig aggregates. In order to capitalize on the known antiinflammatory and tolerogenic properties… read more here.
Keywords: recombinant human; human igg1; igg1 multimer; ivig ... See more keywords