Experimental Human Infection with Neisseria gonorrhoeae.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9496-0_25
Abstract: Experimental infection of male volunteers with Neisseria gonorrhoeae is safe and reproduces the clinical features of naturally acquired gonococcal urethritis. The human model is useful for testing the importance of putative gonococcal virulence factors for… read more here.
Keywords: human infection; infection neisseria; infection; neisseria gonorrhoeae ... See more keywords
The First Reported Outbreak of an Undetermined Species of Human Infection with Spotted Fever Group Rickettsia in Lu'an, China.
Sign Up to like & getrecommendations! Published in 2021 at "Acta tropica"
DOI: 10.1016/j.actatropica.2021.106072
Abstract: OBJECTIVE On May 2, 2017, an outbreak of unexplained fever with rashes was reported in Lu'an, China. In this study, we aimed to identify the possible pathogens, epidemiological characteristics, and risk factors of this outbreak.… read more here.
Keywords: first reported; human infection; outbreak undetermined; undetermined species ... See more keywords
The effect of salting on Toxoplasma gondii viability evaluated and implemented in a quantitative risk assessment of meat-borne human infection.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of food microbiology"
DOI: 10.1016/j.ijfoodmicro.2019.108380
Abstract: The protozoan parasite Toxoplasma gondii can infect all warm-blooded animals and it causes the disease toxoplasmosis. Meat containing viable T. gondii tissue cysts is considered one of the main sources of human infection. The relative… read more here.
Keywords: human infection; meat borne; gondii; quantitative risk ... See more keywords
A review on current trends in the treatment of human infection with H7N9-avian influenza A.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of infection and public health"
DOI: 10.1016/j.jiph.2018.08.005
Abstract: The H7N9 subtype of avian influenza is an enzootic and airborne virus which caused an influenza outbreak in China. Infected individuals mostly worked with poultry, suggesting H7N9 virus-infected poultry as the primary source of human… read more here.
Keywords: avian influenza; human infection; infection; h7n9 avian ... See more keywords
The Case for Modeling Human Infection in Zebrafish.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in microbiology"
DOI: 10.1016/j.tim.2019.08.005
Abstract: Zebrafish (Danio rerio) larvae are widely recognized for studying host-pathogen interactions in vivo because of their optical transparency, genetic manipulability, and translational potential. The development of the zebrafish immune system is well understood, thereby use of… read more here.
Keywords: human infection; infection zebrafish; modeling human; case modeling ... See more keywords
Controlled human infection with RSV: The opportunities of experimental challenge.
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2016.08.086
Abstract: Despite the recent explosion in RSV vaccine development, there remain substantial hurdles to overcome before licensing of effective vaccines will allow widespread use, particularly in high-risk populations. Incomplete understanding of mechanisms and correlates of protection… read more here.
Keywords: human infection; challenge; controlled human; infection ... See more keywords
Emergence of waterfowl‐originated gene cassettes in HPAI H7N9 viruses caused severe human infection in Fujian, China
Sign Up to like & getrecommendations! Published in 2019 at "Influenza and Other Respiratory Viruses"
DOI: 10.1111/irv.12657
Abstract: Highly pathogenic avian influenza (HPAI) A(H7N9) virus emerged and caused human infections during the 2016‐2017 epidemic wave of influenza A(H7N9) viruses in China. We report a human infection with HPAI H7N9 virus and six environmental… read more here.
Keywords: human infection; hpai h7n9; emergence waterfowl; china ... See more keywords
Ethics of controlled human infection to address COVID-19
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.abc1076
Abstract: High social value is fundamental to justifying these studies Development of an effective vaccine is the clearest path to controlling the coronavirus disease 2019 (COVID-19) pandemic. To accelerate vaccine development, some researchers are pursuing, and… read more here.
Keywords: human infection; controlled human; infection; social value ... See more keywords
Targeted Transcriptomic Screen of Pneumococcal Genes Expressed during Murine and Human Infection
Sign Up to like & getrecommendations! Published in 2022 at "Infection and Immunity"
DOI: 10.1128/iai.00175-22
Abstract: The advent of pneumococcal conjugate vaccines led to the near disappearance of most of the included serotypes in high-income settings but also the rise of nonvaccine-type colonization and disease. Alternative strategies, using genetically conserved proteins… read more here.
Keywords: human infection; colonization; transcriptomic screen; infection ... See more keywords
Controlled human infection with Neisseria lactamica in late pregnancy to measure horizontal transmission and microbiome changes in mother–neonate pairs: a single-arm interventional pilot study protocol
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Open"
DOI: 10.1136/bmjopen-2021-056081
Abstract: Introduction Infant upper respiratory microbiota are derived partly from the maternal respiratory tract, and certain microbiota are associated with altered risk of infections and respiratory disease. Neisseria lactamica is a common pharyngeal commensal in young… read more here.
Keywords: human infection; controlled human; nasal inoculation; microbiome ... See more keywords
Controlled human infection with SARS-CoV-2 to study COVID-19 vaccines and treatments: bioethics in Utopia
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medical Ethics"
DOI: 10.1136/medethics-2020-106476
Abstract: A number of papers have appeared recently arguing for the conclusion that it is ethically acceptable to infect healthy volunteers with severe acute respiratory syndrome coronavirus 2 as part of research projects aimed at developing… read more here.
Keywords: vaccines treatments; human infection; covid vaccines; research ... See more keywords