Glucose–methanol‐based fed‐batch fermentation for the production of recombinant human interferon gamma (rhIFN‐γ) and evaluation of its antitumor potential
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1868
Abstract: Squamous cell carcinoma (SCC) is nonmelanoma skin cancer, which is very common in patients having T‐cell immunosuppressant drugs. Anticancerous agents such as cytokines showed effective response on SCC. Human interferon‐gamma (hIFN‐γ), a type II cytokines,… read more here.
Keywords: rhifn; production; human interferon; interferon gamma ... See more keywords
Engineering Chlamydomonas reinhardtii for Expression of Functionally Active Human Interferon-α
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DOI: 10.1007/s12033-018-0143-y
Abstract: Human interferon (IFN) are secreted cytokines that play a major regulatory role in response to various infections. Commercially, IFN-α has been approved to treat many chronic viral diseases as well as a variety of cancers… read more here.
Keywords: human interferon; expression; reinhardtii expression; chlamydomonas reinhardtii ... See more keywords
Stability and Activity of the Hyperglycosylated Human Interferon-β R27T Variant
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DOI: 10.1038/s41598-020-65495-y
Abstract: A hyperglycosylated recombinant human interferon-β (rhIFN-β) R27T mutant was established to improve relapsing-remitting multiple sclerosis (RRMS) in our previous study. We focused on the stability of the R27T mutant throughout its production lifetime, including culture,… read more here.
Keywords: stability; culture purification; r27t; human interferon ... See more keywords
Investigation into the pharmacodynamics and pharmacokinetics of recombinant human interferon alfa-2b vaginal suppository following process optimization in chinese rhesus macaque
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DOI: 10.1038/s41598-025-98813-3
Abstract: Recombinant human interferon Alfa-2b vaginal suppository is a gynecological preparation mainly made of interferon, commonly used to treat diseases related to viral infections such as cervical erosion. As a recombinant protein drug, it is important… read more here.
Keywords: process; human interferon; alfa vaginal; recombinant human ... See more keywords
Genetic and substrate-level modulation of Bacillus subtilis physiology for enhanced extracellular human interferon gamma production
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DOI: 10.1080/10826068.2018.1446157
Abstract: ABSTRACT Human interferon-gamma (hIFNG) production is limited by various gene-level bottlenecks including translation, protein folding, and secretion which depends upon the physiological state of the organism. In this study gene-level and substrate-level modulations have been… read more here.
Keywords: production; level; physiology; interferon gamma ... See more keywords
Retracted: Human Interferon Inducible Transmembrane Protein 3 (IFITM3) Inhibits Influenza Virus A Replication and Inflammation by Interacting with ABHD16A
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DOI: 10.1155/2022/9790782
Abstract: [This retracts the article DOI: 10.1155/2021/6652147.]. read more here.
Keywords: inducible transmembrane; interferon inducible; retracted human; human interferon ... See more keywords
Shared and Unique Features of Human Interferon-Beta and Interferon-Alpha Subtypes
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DOI: 10.3389/fimmu.2020.605673
Abstract: Type I interferons (IFN-I) were first discovered as an antiviral factor by Isaacs and Lindenmann in 1957, but they are now known to also modulate innate and adaptive immunity and suppress proliferation of cancer cells.… read more here.
Keywords: interferon beta; shared unique; interferon; features human ... See more keywords
A Biotechnological Approach for the Production of Pharmaceutically Active Human Interferon-α from Raphanus sativus L. Plants
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DOI: 10.3390/bioengineering9080381
Abstract: Human interferon (IFN) is a type of cytokine that regulates the immune system’s response to viral and bacterial infections. Recombinant IFN-α has been approved for use in the treatment of a variety of viral infections… read more here.
Keywords: ifn; raphanus sativus; sativus plants; human interferon ... See more keywords