A Bioprinted Tubular Intestine Model using a Colon-Specific Extracellular Matrix Bioink.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202101768
Abstract: Tremendous advances have been made toward accurate recapitulation of the human intestinal system in vitro to understand its developmental process, and disease progression. However, current in vitro models are often confined to 2D or 2.5D… read more here.
Keywords: extracellular matrix; tissue; colon; model ... See more keywords
In vitro human intestinal microbiota biotransformation of nobiletin using LC-MS analysis and background subtraction strategy.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of separation science"
DOI: 10.1002/jssc.202001150
Abstract: In this study, the in vitro biotransformation of nobiletin by human intestinal microbiota, which is a bioactive polymethoxyflavone widely presented in Citrus plants, has been investigated via utilizing an anaerobic incubation protocol. The incubation samples… read more here.
Keywords: biotransformation nobiletin; intestinal microbiota; subtraction strategy; background subtraction ... See more keywords
In vitro sensitivity of 30 anaerobic bacterial strains of the human intestinal core microbiota to antibiotics: culture and LC-MS/MS approaches.
Sign Up to like & getrecommendations! Published in 2020 at "Anaerobe"
DOI: 10.1016/j.anaerobe.2020.102314
Abstract: We have a vast knowledge on human intestinal microbiota but it can still be regarded incomplete. One of the objectives of scientists using so-called "omics" techniques is to be interested in the consequences that drugs… read more here.
Keywords: microbiota; intestinal core; sensitivity; core microbiota ... See more keywords
Tissue Responses to Shiga Toxin in Human Intestinal Organoids
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2020.02.006
Abstract: Background & Aims Shiga toxin (Stx)-producing Escherichia coli (eg, O157:H7) infection produces bloody diarrhea, while Stx inhibits protein synthesis and causes the life-threatening systemic complication of hemolytic uremic syndrome. The murine intestinal tract is resistant… read more here.
Keywords: tissue; tissue responses; shiga toxin; human intestinal ... See more keywords
Identification of naringin metabolites mediated by human intestinal microbes with stable isotope‐labeling method and UFLC‐Q‐TOF‐MS/MS
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.08.039
Abstract: HighlightsA total of 13 naringin metabolites mediated by human intestinal microbes were identified, among which 5 were reported for the first time.Naringin underwent extensive phase I metabolism in human intestinal microbes.Microbial metabolic profiles of naringin… read more here.
Keywords: intestinal microbes; isotope labeling; mediated human; labeling method ... See more keywords
Human gastrointestinal metabolism of the anti-rheumatic fraction of Dianbaizhu (Gaultheria leucocarpa var. yunnanensis) in vitro: Elucidation of the metabolic analysis in gastric juice, intestinal juice and human intestinal bacteria by UPLC-LTQ-Orbitrap-MSn and HPLC-DAD.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2019.112791
Abstract: The anti-rheumatic fraction (ARF), is responsible for the anti-inflammatory and analgesic effects of Dianbaizhu derived from the aerial part of Gaultheria leucocarpa var. yunnanensis (Ericaceae). The gastrointestinal metabolism of ARF was investigated in vitro through… read more here.
Keywords: anti rheumatic; rheumatic fraction; intestinal bacteria; gaultheria leucocarpa ... See more keywords
Transplantation of human intestinal organoids into the mouse mesentery: A more physiologic and anatomic engraftment site
Sign Up to like & getrecommendations! Published in 2018 at "Surgery"
DOI: 10.1016/j.surg.2018.04.048
Abstract: Background: We previously described the development of human intestinal organoids from pluripotent stem cells, as well as their in vivo maturation when transplanted into the mouse kidney capsule. While sufficient for certain aspects of study,… read more here.
Keywords: human intestinal; mouse mesentery; intestinal organoids; transplantation human ... See more keywords
Interindividual Differences in Human Intestinal Microbial Conversion of (−)-Epicatechin to Bioactive Phenolic Compounds
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Agricultural and Food Chemistry"
DOI: 10.1021/acs.jafc.0c05890
Abstract: To quantify interindividual differences in the human intestinal microbial metabolism of (−)-epicatechin (EC), in vitro anaerobic incubations with fecal inocula from 24 healthy donors were conducted. EC-derived colonic microbial metabolites were qualitatively and quantitively analyzed… read more here.
Keywords: intestinal microbial; microbial conversion; human intestinal; differences human ... See more keywords
Biotransformation of 18β-Glycyrrhetinic Acid by Human Intestinal Fungus Aspergillus niger RG13B1 and the Potential Anti-Inflammatory Mechanism of Its Metabolites.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c05455
Abstract: 18β-Glycyrrhetinic acid (GA) is a triterpenoid possessing an anti-inflammatory activity in vivo, while the low bioavailability limits its application due to its intestinal accumulation. In order to investigate the metabolism of GA in intestinal microbes,… read more here.
Keywords: fungus aspergillus; intestinal fungus; glycyrrhetinic acid; anti inflammatory ... See more keywords
Curcuminoid Demethylation as an Alternative Metabolism by Human Intestinal Microbiota.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.7b00943
Abstract: Curcumin and other curcuminoids from Curcuma longa are important bioactive compounds exhibiting various pharmacological activities. In addition to the known reductive metabolism of curcuminoids, an alternative biotransformation of curcuminoids by human gut microbiota is reported… read more here.
Keywords: microbiota; metabolism; curcuminoid demethylation; human intestinal ... See more keywords
Lipidomics Provides Novel Insights into Understanding the Bee Pollen Lipids Transepithelial Transport and Metabolism in Human Intestinal Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b06531
Abstract: Bee pollen (BP) shows profound gut-protecting potentials. BP lipids (BPL) mainly composed by phospholipids and polyunsaturated fatty acids might be one of the important contributors, while how BPL exerts gut-protecting effects and transports through intestinal… read more here.
Keywords: human intestinal; cell; transport; bee pollen ... See more keywords