Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention.
Sign Up to like & getrecommendations! Published in 2020 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.12.005
Abstract: Type 1 diabetes (T1D) results from the progressive loss of β cells, a process propagated by pro-inflammatory cytokine signaling that disrupts the balance between pro- and anti-apoptotic proteins. To identify proteins involved in this process,… read more here.
Keywords: comprehensive proteomics; human islets; target; proteomics analysis ... See more keywords
Activation of imidazoline receptor I2, and improved pancreatic β-cell function in human islets.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of diabetes and its complications"
DOI: 10.1016/j.jdiacomp.2018.06.010
Abstract: AIM The impact of BL11282, an imidazoline receptor (NISCH) agonist, on potentiation of glucose-stimulated insulin secretion (GSIS) from isolated human non-diabetic (ND) and type 2 diabetic (T2D) islets was investigated. METHODS Analysis of mRNA was… read more here.
Keywords: bl11282; imidazoline receptor; camp; human islets ... See more keywords
Syndecan-4 is regulated by IL-1β in β-cells and human islets
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2020.110815
Abstract: Syndecans (SDC) are important multifunctional components of the extracellular matrix mainly described in endothelial cells. We studied the expression and regulation of SDC in cultured MIN6B1 cells and pancreatic islets. qRT-PCR revealed that syndecan-4 (SDC4)… read more here.
Keywords: human islets; sdc4; syndecan regulated; regulated cells ... See more keywords
Human islets contain a subpopulation of glucagon-like peptide-1 secreting α cells that is increased in type 2 diabetes
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2020.101014
Abstract: Objectives Our study shows that glucagon-like peptide-1 (GLP-1) is secreted within human islets and may play an unexpectedly important paracrine role in islet physiology and pathophysiology. It is known that α cells within rodent and… read more here.
Keywords: glucagon like; human islets; glp; type diabetes ... See more keywords
Vascularization of human islets by adaptable endothelium for durable and functional subcutaneous engraftment
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DOI: 10.1126/sciadv.adq5302
Abstract: Tissue-specific endothelial cells (ECs) are critical for the homeostasis of pancreatic islets and most other tissues. In vitro recapitulation of islet biology and therapeutic islet transplantation both require adequate vascularization, which remains a challenge. Using… read more here.
Keywords: vascularization; vascularization human; adaptable endothelium; islets adaptable ... See more keywords
Vessel Network Architecture of Adult Human Islets Promotes Distinct Cell-Cell Interactions In Situ and Is Altered After Transplantation
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DOI: 10.1210/en.2016-1184
Abstract: Islet-cell hormone release is modulated by signals from endothelial and endocrine cells within the islet. However, models of intraislet vascularization and paracrine cell signaling are mostly based on the rodent pancreas. We assessed the architecture… read more here.
Keywords: network; human islets; islet; transplantation ... See more keywords
Dapagliflozin does not directly affect human α or β cells.
Sign Up to like & getrecommendations! Published in 2020 at "Endocrinology"
DOI: 10.1210/endocr/bqaa080
Abstract: Selective inhibitors of sodium glucose cotransporter-2 (SGLT2) are widely used for the treatment of type 2 diabetes (T2D) and act primarily to lower blood glucose by preventing glucose reabsorption in the kidney. However, it is… read more here.
Keywords: glucagon; secretion; human islets; treatment ... See more keywords
Acute Inhibition of Adipose Triglyceride Lipase by NG497 Dysregulates Insulin and Glucagon Secretion From Human Islets
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DOI: 10.1210/endocr/bqaf090
Abstract: Abstract Adipose triglyceride lipase (ATGL), which catalyzes the breakdown of triglycerides in lipid droplets (LDs), plays a critical role in releasing fatty acids to support insulin secretion in pancreatic β cells. Based on genetic downregulation… read more here.
Keywords: insulin secretion; triglyceride lipase; secretion; adipose triglyceride ... See more keywords
Coxsackievirus-Induced Proteomic Alterations in Primary Human Islets Provide Insights for the Etiology of Diabetes
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2017-00278
Abstract: Enteroviral infections have been associated with the development of type 1 diabetes (T1D), a chronic inflammatory disease characterized by autoimmune destruction of insulin-producing pancreatic beta cells. Cultured human islets, including the insulin-producing beta cells, can… read more here.
Keywords: human islets; etiology; coxsackievirus induced; proteomic alterations ... See more keywords
CLEC11A improves insulin secretion and promotes cell proliferation in human beta-cells.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-22-0066
Abstract: Beta-cell dysfunction is a hallmark of disease progression in patients with diabetes. Research have been focused on maintaining and restoring beta-cell function during diabetes development. The aims of this study were to explore the expression… read more here.
Keywords: cell; proliferation; beta; human islets ... See more keywords
High Concentrations of Etanercept Reduce Human Islet Function and Integrity
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DOI: 10.2147/jir.s294663
Abstract: Background Most islet transplant groups worldwide routinely use the TNFα inhibitor Etanercept in their peri-transplant protocols. Surprisingly, there have been no published dose-response studies on the effects of Etanercept on human islets. Our study aimed… read more here.
Keywords: human islets; islet; concentrations etanercept; high concentrations ... See more keywords