Capturing the Dynamic Conformational Changes of Human Isocitrate Dehydrogenase 1 (IDH1) upon Ligand and Metal Binding Using Hydrogen-Deuterium Exchange Mass Spectrometry.
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DOI: 10.1021/acs.biochem.2c00636
Abstract: Human isocitrate dehydrogenase 1 (IDH1) is a highly conserved metabolic enzyme that catalyzes the interconversion of isocitrate and α-ketoglutarate. Kinetic and structural studies with IDH1 have revealed evidence of striking conformational changes that occur upon… read more here.
Keywords: dehydrogenase idh1; isocitrate dehydrogenase; conformational changes; human isocitrate ... See more keywords