Usefulness of Human Jejunal Spheroid–Derived Differentiated Intestinal Epithelial Cells for the Prediction of Intestinal Drug Absorption in Humans
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.121.000796
Abstract: This study aimed to demonstrate the usefulness of human jejunal spheroid-derived differentiated intestinal epithelial cells as a novel in vitro model for clarifying the impact of intestinal drug-metabolizing enzymes and transporters on the intestinal absorption… read more here.
Keywords: drug; spheroid derived; human jejunal; differentiated intestinal ... See more keywords
βHB inhibits glucose-induced GLP-1 secretion in GLUTag and human jejunal enteroids.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-22-0115
Abstract: Ingestion of nutrients stimulates incretin secretion from the enteroendocrine cells (EECs) of the epithelial layer of the gut. Glucagon-like peptide-1 (GLP-1) is one of these incretins that stimulates postprandial insulin release and signals satiety to… read more here.
Keywords: glp secretion; glucose induced; glutag; human jejunal ... See more keywords