Analysis of global DNA methylation changes in human keratinocytes immediately following exposure to a 900 MHz radiofrequency field
Sign Up to like & getrecommendations! Published in 2023 at "Bioelectromagnetics"
DOI: 10.1002/bem.22439
Abstract: The increasing use of nonionizing radiofrequency electromagnetic fields (RF‐EMFs) in a wide range of technologies necessitates studies to further understanding of biological effects from exposures to such forms of electromagnetic fields. While previous studies have… read more here.
Keywords: human keratinocytes; following exposure; dna methylation; exposure ... See more keywords
ROS‐challenged keratinocytes as a new model for oxidative stress‐mediated skin diseases
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27485
Abstract: In the current study, the effects of the reactive oxygen species (ROS) generator 2,2′‐azobis(2‐amidinopropane) dihydrochloride (AAPH) on extracellular and intracellular ROS production in human keratinocytes (HACAT) were studied. AAPH is a water‐soluble compound able to… read more here.
Keywords: aaph; skin; model; human keratinocytes ... See more keywords
Folic acid-layered double hydroxides hybrids in skin formulations: Technological, photochemical and in vitro cytotoxicity on human keratinocytes and fibroblasts
Sign Up to like & getrecommendations! Published in 2019 at "Applied Clay Science"
DOI: 10.1016/j.clay.2018.12.009
Abstract: Abstract Folic acid (FA) is a key factor in the physiological processes of cell metabolism; as it is involved in DNA synthesis and repair, it can be used in the treatment of aged and photo-damaged… read more here.
Keywords: double hydroxides; folic acid; hydroxides hybrids; layered double ... See more keywords
Coordinated collective migration and asymmetric cell division in confluent human keratinocytes without wounding
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05578-7
Abstract: Epithelial sheet spreading is a fundamental cellular process that must be coordinated with cell division and differentiation to restore tissue integrity. Here we use consecutive serum deprivation and re-stimulation to reconstruct biphasic collective migration and… read more here.
Keywords: coordinated collective; cell division; migration; collective migration ... See more keywords
Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10646-7
Abstract: Recently our groups discovered lugdunin, a new cyclic peptide antibiotic that inhibits Staphylococcus aureus epithelial colonization in humans and rodents. In this work, we analyzed its immuno-modulatory and antimicrobial potential as a single agent or… read more here.
Keywords: microbiota; derived factors; keratinocytes mouse; host ... See more keywords
Exome sequencing identifies novel mutation signatures of UV radiation and trichostatin A in primary human keratinocytes
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-61807-4
Abstract: Canonical ultraviolet (UV) mutation type and spectra are traditionally defined by direct sequencing-based approaches to map mutations in a limited number of representative DNA elements. To obtain an unbiased view of genome wide UV mutation… read more here.
Keywords: exome sequencing; identifies novel; novel mutation; human keratinocytes ... See more keywords
A single dose of Ultraviolet-A induces proteome remodeling and senescence in primary human keratinocytes
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-02658-5
Abstract: Epidermal photoaging contributes to skin fragility over time and it is a risk factor for skin cancer. Photoaging has been associated for a long time with exposure to Ultraviolet-A (UVA) light, the predominant component of… read more here.
Keywords: senescence primary; primary human; remodeling senescence; proteome remodeling ... See more keywords
Activation of the NLRP1 inflammasome in human keratinocytes by the dsDNA mimetic poly(dA:dT).
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2213777120
Abstract: The accrual of cytosolic DNA leads to transcription of type I IFNs, proteolytic maturation of the IL-1 family of cytokines, and pyroptotic cell death. Caspase-1 cleaves pro-IL1β to generate mature bioactive cytokine and gasdermin D… read more here.
Keywords: human keratinocytes; dsdna mimetic; activate nlrp1; poly ... See more keywords
Miconazole and terbinafine induced reactive oxygen species accumulation and topical toxicity in human keratinocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Drug and chemical toxicology"
DOI: 10.1080/01480545.2020.1778019
Abstract: There are an estimated 1 billion cases of superficial fungal infection globally. Fungal pathogens form biofilms within wounds and delay the wound healing process. Miconazole and terbinafine are commonly used to treat fungal infections. They… read more here.
Keywords: reactive oxygen; terbinafine induced; oxygen species; miconazole terbinafine ... See more keywords
IL‐38 orchestrates proliferation and differentiation in human keratinocytes
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Dermatology"
DOI: 10.1111/exd.14644
Abstract: Interleukin (IL)‐38 is a member of the IL‐1 cytokine family with reported anti‐inflammatory activity. The highest constitutive IL‐38 expression is detected in the skin, where it is mainly produced by differentiating keratinocytes. However, little data… read more here.
Keywords: human keratinocytes; proliferation; orchestrates proliferation; differentiation human ... See more keywords
Oleracone C from Portulaca oleracea attenuates UVB‐induced changes in matrix metalloproteinase and type I procollagen production via MAPK and TGF‐β/Smad pathways in human keratinocytes
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cosmetic Science"
DOI: 10.1111/ics.12828
Abstract: Chronic exposure to ultraviolet (UV) radiation induces photo‐oxidation, which in turn causes the overproduction of matrix metalloproteinases (MMPs) and collagen degradation. These symptoms are referred to as photoaging, which is characterized by skin thickness, irregular… read more here.
Keywords: induced changes; human keratinocytes; uvb induced; type procollagen ... See more keywords