Human Kinases Display Mutational Hotspots at Cognate Positions Within Cancer
Sign Up to like & getrecommendations! Published in 2017 at "Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing"
DOI: 10.1142/9789813207813_0039
Abstract: The discovery of driver genes is a major pursuit of cancer genomics, usually based on observing the same mutation in different patients. But the heterogeneity of cancer pathways plus the high background mutational frequency of… read more here.
Keywords: kinases display; kinase paralogs; display mutational; human kinases ... See more keywords
Comparative expression of soluble, active human kinases in specialized bacterial strains
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0267226
Abstract: Kinases act as molecular switches for cellular functions and are involved in multiple human pathogeneses, most notably cancer. There is a continuous need for soluble and active kinases for in-vitro drug discovery and structural biology… read more here.
Keywords: expression; kinase; human kinases; soluble active ... See more keywords