Metagenomic Analysis of Human Lens Microbiota Associated with Ophthalmic Diseases
Sign Up to like & getrecommendations! Published in 2017 at "BioNanoScience"
DOI: 10.1007/s12668-016-0346-2
Abstract: Keratoconus is an ophthalmological pathology which is manifested in noninflammatory conical protrusion of the central part of the cornea. Its etiology is still unknown and pathogenesis is poorly explored. There are number of reports supporting… read more here.
Keywords: analysis; analysis human; metagenomic analysis; lens microbiota ... See more keywords
JNK1/β-catenin axis regulates H2O2-induced epithelial-to-mesenchymal transition in human lens epithelial cells.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.02.049
Abstract: Epithelial-mesenchymal transition (EMT) is the main cause of fibrotic cataracts. Oxidative stress was recently shown to trigger epithelial-mesenchymal transition in human lens epithelial cells (hLECs). However, the underlying mechanism is not fully understood. Here we… read more here.
Keywords: mesenchymal transition; epithelial mesenchymal; human lens; h2o2 induced ... See more keywords
Quantification of thioether‐linked glutathione modifications in human lens proteins
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2018.06.002
Abstract: Abstract Dehydroalanine (DHA) and dehydrobutyrine (DHB) intermediates, formed through &bgr;‐elimination, induce protein irreversible glutathionylation and protein‐protein crosslinking in human lens fiber cells. In total, irreversible glutathionylation was detected on 52 sites including cysteine, serine and… read more here.
Keywords: protein; gsh modification; lens proteins; age ... See more keywords
Age-related spatial differences of human lens UV filters revealed by negative ion mode MALDI imaging mass spectrometry.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental eye research"
DOI: 10.1016/j.exer.2019.04.016
Abstract: Tryptophan-derived UV filters are predominantly found in the lenses of primates and humans. While protective against UV radiation, aging alters the complement and spatial distributions of human lens UV filters, and a role for UV… read more here.
Keywords: age related; age; lens filters; ion ... See more keywords
Copper Reductase Activity and Free Radical Chemistry by Cataract-Associated Human Lens γ-Crystallins.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c13397
Abstract: Cataracts are caused by high-molecular-weight aggregates of human eye lens proteins that scatter light, causing lens opacity. Metal ions have emerged as important potential players in the etiology of cataract disease, as human lens γ-crystallins… read more here.
Keywords: human lens; lens crystallins; chemistry; radical chemistry ... See more keywords
GJA8 missense mutation disrupts hemichannels and induces cell apoptosis in human lens epithelial cells
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-55549-1
Abstract: Autosomal dominant congenital cataract (ADCC), the most common hereditary disease, is a major cause of eye disease in children. Due to its high genetic and clinical heterogeneity, the identification of ADCC-associated gene mutations is essential… read more here.
Keywords: mutation; mutation disrupts; epithelial cells; lens epithelial ... See more keywords
HMOX1 Promotes Ferroptosis Induced by Erastin in Lens Epithelial Cell through Modulates Fe2+ Production
Sign Up to like & getrecommendations! Published in 2022 at "Current Eye Research"
DOI: 10.1080/02713683.2022.2138450
Abstract: Abstract Purpose Ferroptosis is defined by the iron-dependent cell death caused by the accumulation of lipid peroxidation. As a major intracellular Fe pools, heme could be metabolized into ferrous iron, carbon monoxide, and biliverdin by… read more here.
Keywords: cell death; human lens; cell; iron ... See more keywords
Effects of ionizing radiation on telomere length and telomerase activity in cultured human lens epithelium cells
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Radiation Biology"
DOI: 10.1080/09553002.2018.1466066
Abstract: Abstract Purpose: To investigate the effects of ionizing radiation on telomere length and telomerase activity in human lens epithelial cells. There are studies suggesting evidence of telomere length in association with opacity of the lens;… read more here.
Keywords: telomerase activity; telomere length; length telomerase; human lens ... See more keywords
Proteomic characterization of the human lens and Cataractogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Expert Review of Proteomics"
DOI: 10.1080/14789450.2021.1913062
Abstract: ABSTRACT Introduction The goal of this review is to highlight the triumphs and frontiers in measurement of the lens proteome as it relates to onset of age-related nuclear cataract. As global life expectancy increases, so… read more here.
Keywords: lens cataractogenesis; age related; proteomic characterization; characterization human ... See more keywords
Ionizing radiation response of primary normal human lens epithelial cells
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DOI: 10.1371/journal.pone.0181530
Abstract: Whilst the cataractogenic potential of ionizing radiation has been known for over the past 120 years, little is known about radiation responses of lens cells. Our previous work was the first to evaluate the radiosensitivity… read more here.
Keywords: lens epithelial; ionizing radiation; hlec1 cells; human lens ... See more keywords
In vitro inhibition of proliferation, migration and epithelial-mesenchymal transition of human lens epithelial cells by fasudil.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2018.08.02
Abstract: AIM To study the potential role of fasudil as a treatment for posterior capsular opacification (PCO) of the human crystalline lens. METHODS Human lens epithelial cells (HLECs; line SRA01/04) was exposed to transforming growth factor-β2… read more here.
Keywords: proliferation migration; fasudil; proliferation; migration ... See more keywords