Ageing Throughout History: The Evolution of Human Lifespan
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Evolution"
DOI: 10.1007/s00239-019-09896-2
Abstract: It is not surprising that one of the most complex phenomena in nature is that of ageing. It does not only bear biological interest, but it is also associated with cultural, psychological, social and even… read more here.
Keywords: ageing throughout; evolution; human lifespan; evolution human ... See more keywords
"Best-Guess" MRAD Provides Robust Evidence for a Limit to Human Lifespan: Reply to de Grey (Rejuvenation Res. 2017;20:261-262).
Sign Up to like & getrecommendations! Published in 2017 at "Rejuvenation research"
DOI: 10.1089/rej.2017.2008
Abstract: Using segmented linear regression to reanalyze the "best-guess" maximum reported age at death data supplied in Aubrey de Grey's editorial, we find compelling evidence for a breakpoint in the mid-1990s, with a positive slope before… read more here.
Keywords: evidence limit; human lifespan; evidence; best guess ... See more keywords
The Aging Slow Wave: A Shifting Amalgam of Distinct Slow Wave and Spindle Coupling Subtypes Define Slow Wave Sleep Across the Human Lifespan.
Sign Up to like & getrecommendations! Published in 2021 at "Sleep"
DOI: 10.1093/sleep/zsab125
Abstract: STUDY OBJECTIVES Slow wave and spindle coupling supports memory consolidation, and loss of coupling is linked with cognitive decline and neurodegeneration. Coupling is proposed to be a possible biomarker of neurological disease, yet little is… read more here.
Keywords: human lifespan; wave spindle; wave; spindle coupling ... See more keywords
Bacteria in the ageing gut: did the taming of fire promote a long human lifespan?
Sign Up to like & getrecommendations! Published in 2018 at "Environmental Microbiology"
DOI: 10.1111/1462-2920.14255
Abstract: Unique among animals as they evolved towards Homo sapiens, hominins progressively cooked their food on a routine basis. Cooked products are characterized by singular chemical compounds, derived from the pervasive Maillard reaction. This same reaction… read more here.
Keywords: gut; human lifespan; bacteria ageing; taming fire ... See more keywords
Is it better to die than to be lonely?
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Medical Ethics"
DOI: 10.1136/medethics-2017-104511
Abstract: In a sophisticated student essay, Isabelle L Robertson considers the possibility of using germline editing to extend the human lifespan. There is a longstanding debate in the bioethics and enhancement literature about the ethics of… read more here.
Keywords: human lifespan; die lonely; lifespan; life ... See more keywords
Dynamic Changes of Brain Cilia Transcriptomes across the Human Lifespan
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms221910387
Abstract: Almost all brain cells contain primary cilia, antennae-like microtubule sensory organelles, on their surface, which play critical roles in brain functions. During neurodevelopmental stages, cilia are essential for brain formation and maturation. In the adult… read more here.
Keywords: age; brain cilia; brain; human lifespan ... See more keywords