Mass spectrometry‐based abundance atlas of ABC transporters in human liver, gut, kidney, brain and skin
Sign Up to like & getrecommendations! Published in 2020 at "Febs Letters"
DOI: 10.1002/1873-3468.13982
Abstract: ABC transporters (ATP‐binding cassette transporter) traffic drugs and their metabolites across membranes, making ABC transporter expression levels a key factor regulating local drug concentrations in different tissues and individuals. Yet, quantification of ABC transporters remains… read more here.
Keywords: abc transporters; mass spectrometry; abundance; brain ... See more keywords
Decellularized Liver Nanofibers Enhance and Stabilize the Long-term Functions of Primary Human Hepatocytes In Vitro.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202202302
Abstract: Owing to significant differences across species in liver functions, in vitro human liver models are used for screening the metabolism and toxicity of compounds, modeling diseases, and cell-based therapies. However, the extracellular matrix (ECM) scaffold… read more here.
Keywords: human hepatocytes; liver; primary human; topography ... See more keywords
Engineering human liver fatty acid binding protein for detection of poly- and perfluoroalkyl substances.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.27981
Abstract: Per- and polyfluoroalkyl substances (PFAS) are a large group of synthetic fluorinated chemicals with surface active and water-repellent properties. The combination of wide-spread use in numerous consumer and industrial products and extended biological half-lives arising… read more here.
Keywords: detection; water; liver fatty; fatty acid ... See more keywords
Modelling Human Liver Microphysiology on a Chip Through a Finite Element Based Design Approach.
Sign Up to like & getrecommendations! Published in 2021 at "International journal for numerical methods in biomedical engineering"
DOI: 10.1002/cnm.3445
Abstract: Organ-on-a-chip are microfluidic devices capable of growing living tissue and replicate the intricate microenvironments of human organs in vitro, being heralded as having the potential to revolutionize biological research and healthcare by enabling unprecedented control… read more here.
Keywords: finite element; approach; human liver; chip ... See more keywords
Metabolic profiling of synthetic cannabinoid 5F-ADB by human liver microsome incubations and urine samples using high-resolution mass spectrometry.
Sign Up to like & getrecommendations! Published in 2019 at "Drug testing and analysis"
DOI: 10.1002/dta.2566
Abstract: 5F-ADB (methyl 2-{[1-(5-fluoropentyl)-1H-indazole-3-carbonyl] amino}-3,3-dimethylbutanoate) is a frequently abused new synthetic cannabinoid that has been sold since at least the end of 2014 on the drug market and has been classified as an illicit drug in… read more here.
Keywords: high resolution; synthetic cannabinoid; drug; adb ... See more keywords
Metabolic Profiling of Deschloro-N-Ethyl-Ketamine and Identification of New Target Metabolites in Urine and Hair using Human Liver Microsomes and High-Resolution Accurate Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2021 at "Drug testing and analysis"
DOI: 10.1002/dta.3007
Abstract: The aim of this study was to identify new markers of deschloro-N-ethyl-ketamine (O-PCE), a ketamine analogue that has been involved in acute intoxications with sever outcomes including death and whose metabolism has never been studied… read more here.
Keywords: deschloro ethyl; hair; pce; urine hair ... See more keywords
The metabolism of valerylfentanyl using human liver microsomes and zebrafish larvae.
Sign Up to like & getrecommendations! Published in 2022 at "Drug testing and analysis"
DOI: 10.1002/dta.3233
Abstract: Valerylfentanyl-a novel synthetic opioid, less potent than fentanyl, has been reported in biological samples, but there are limited studies on its pharmacokinetic properties. The goal of this study was to elucidate the metabolism of valerylfentanyl… read more here.
Keywords: liver; valerylfentanyl using; liver microsomes; valerylfentanyl ... See more keywords
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk.
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32802
Abstract: BACKGROUND AND AIMS Major genomic drivers of hepatocellular carcinoma (HCC) are nowadays well recognized, although models to establish their roles in human HCC initiation remain scarce. Here, we used human liver organoids in experimental systems to… read more here.
Keywords: r249s mutation; hcc; liver organoids; tp53 ... See more keywords
Monocarbonyl curcuminoids as antituberculosis agents with their moderate in‐vitro metabolic stability on human liver microsomes
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22754
Abstract: Tuberculosis, an airborne infectious disease, results in a high morbidity and mortality rate. The continuous emergence of TB resistance strains including MDR (multidrug‐resistant tuberculosis), XDR (extensive drug‐resistant tuberculosis), and especially TDR (totally drug‐resistant tuberculosis) is… read more here.
Keywords: vitro metabolic; metabolic stability; monocarbonyl curcuminoids; tuberculosis ... See more keywords
Free‐breathing 3D CEST MRI of human liver at 3.0 T
Sign Up to like & getrecommendations! Published in 2022 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.29470
Abstract: To develop a novel 3D abdominal CEST MRI technique at 3 T using MR multitasking, which enables entire‐liver coverage with free‐breathing acquisition. read more here.
Keywords: free breathing; mri human; cest mri; breathing cest ... See more keywords
Cytotoxicity of novel fluorinated alternatives to long-chain perfluoroalkyl substances to human liver cell line and their binding capacity to human liver fatty acid binding protein
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Toxicology"
DOI: 10.1007/s00204-017-2055-1
Abstract: Although shorter chain homologues and other types of fluorinated chemicals are currently used as alternatives to long-chain perfluoroalkyl substances (PFASs), their safety information remains unclear and urgently needed. Here, the cytotoxicity of several fluorinated alternatives… read more here.
Keywords: long chain; alternatives long; hfpo; acid ... See more keywords