Bioengineered Mini Human Livers for Transplantation
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31528
Abstract: The only curative treatment for end-stage liver disease is liver transplantation. However, a shortage of donor organs, financial burden on the patients, and the need for lifelong immunosuppression are major limitations. One potential solution to… read more here.
Keywords: bioengineered mini; livers transplantation; human livers; transplantation ... See more keywords
Histological quantification of decomposed human livers: a potential aid for estimation of the post-mortem interval?
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Legal Medicine"
DOI: 10.1007/s00414-020-02467-x
Abstract: The objective of this study was to determine if a novel scoring-based model for histological quantification of decomposed human livers could improve the precision of post-mortem interval (PMI) estimation for bodies from an indoor setting.… read more here.
Keywords: estimation; histological quantification; post mortem; human livers ... See more keywords
Multi-parametric analysis of human livers reveals variation in intrahepatic inflammation across phases of chronic hepatitis B infection.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2022.02.016
Abstract: BACKGROUND AND AIMS Chronic HBV is clinically defined in 4 phases by a combination of serum HBV DNA levels, HBeAg status and ALT: immunotolerant (IT), immune-active (IA), inactive carrier (IC) and HBeAg-negative hepatitis (ENEG). Immune… read more here.
Keywords: chronic hbv; parametric analysis; analysis human; human livers ... See more keywords
Supercooling extends preservation time of human livers
Sign Up to like & getrecommendations! Published in 2019 at "Nature biotechnology"
DOI: 10.1038/s41587-019-0223-y
Abstract: The inability to preserve vascular organs beyond several hours contributes to the scarcity of organs for transplantation1,2. Standard hypothermic preservation at +4 °C (refs. 1,3) limits liver preservation to less than 12 h. Our group previously showed… read more here.
Keywords: supercooling extends; extends preservation; livers supercooling; preservation ... See more keywords
An integrated perfusion machine preserves injured human livers for 1 week
Sign Up to like & getrecommendations! Published in 2020 at "Nature Biotechnology"
DOI: 10.1038/s41587-019-0374-x
Abstract: The ability to preserve metabolically active livers ex vivo for 1 week or more could allow repair of poor-quality livers that would otherwise be declined for transplantation. Current approaches for normothermic perfusion can preserve human… read more here.
Keywords: injured human; week; perfusion machine; perfusion ... See more keywords
Microbial Contamination During Long-term Ex Vivo Normothermic Machine Perfusion of Human Livers.
Sign Up to like & getrecommendations! Published in 2023 at "Transplantation"
DOI: 10.1097/tp.0000000000004653
Abstract: BACKGROUND Normothermic machine perfusion permits the ex vivo preservation of human livers before transplantation. Long-term perfusion for days-to-weeks provides the opportunity for enhanced pretransplant assessment and potential regeneration of organs. However, this risks microbial contamination… read more here.
Keywords: long term; perfusion; human livers; microbial contamination ... See more keywords
Methaemoglobinaemia Can Complicate Normothermic Machine Perfusion of Human Livers
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Surgery"
DOI: 10.3389/fsurg.2021.634777
Abstract: Background: Although liver normothermic machine perfusion is increasingly used clinically, there are few reports of complications or adverse events. Many centers perform liver NMP to viability test suboptimal grafts, often for prolonged periods. In addition,… read more here.
Keywords: methaemoglobinaemia; perfusion; normothermic machine; human livers ... See more keywords