Mitochondrial ferritin expression in human macrophages is facilitated by thrombin‐mediated cleavage under hypoxia
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14545
Abstract: Ferritins are iron storage proteins, which maintain cellular iron homeostasis. Among these proteins, the ferritin heavy chain is well characterized, but the regulatory principles of mitochondrial ferritin (FTMT) remain elusive. FTMT appears to be cleaved… read more here.
Keywords: cleavage; mitochondrial ferritin; expression; hypoxia ... See more keywords
Notch signaling increases PPARγ protein stability and enhances lipid uptake through AKT in IL‐4‐stimulated THP‐1 and primary human macrophages
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12858
Abstract: Notch signaling and nuclear receptor PPARγ are involved in macrophage polarization, but cross talk between them has not been reported in macrophages. In this study, the effect of Notch signaling on PPARγ in IL‐4‐stimulated human… read more here.
Keywords: ppar; akt; ppar protein; protein stability ... See more keywords
Immunometabolic Effect of Nitric Oxide on Human Macrophages Challenged With the SARS‐CoV2‐Induced Cytokine Storm. A Fluxomic Approach
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202401688
Abstract: The cytokine storm associated with SARS‐CoV‐2 infection is one of the most distinctive pathological signatures in COVID‐19 patients. Macrophages respond to this pro‐inflammatory challenge by reprogramming their functional and metabolic phenotypes. Interestingly, human macrophages fail… read more here.
Keywords: storm; effect nitric; immunometabolic effect; cytokine storm ... See more keywords
The Phenotypical and Functional Effect of PGE2 on Human Macrophages
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Immunology"
DOI: 10.1002/eji.70090
Abstract: Prostaglandin E2 (PGE2) is one important immunosuppressive factor within the tumor microenvironment (TME). Signaling through E‐prostanoid receptor type 2 (EP2) and EP4, PGE2 promotes suppressive immune cell phenotypes and impairs antitumor immunity. Blocking PGE2 signaling… read more here.
Keywords: pge2 human; tumor derived; pge2; tumor ... See more keywords
Inflammasome Activation in Human Macrophages Induced by a LDL (−) Mimetic Peptide
Sign Up to like & getrecommendations! Published in 2019 at "Inflammation"
DOI: 10.1007/s10753-019-01159-y
Abstract: The inflammasome is responsible for maturation of interleukin-1β (IL-1β) and interleukin-18 (IL-18) contributing to the inflammatory process in atherosclerosis. It is shown here that an electronegative low-density lipoprotein [LDL (−)] apoB-100 mimetic peptide can activate… read more here.
Keywords: inflammasome activation; activation human; activation; mimetic peptide ... See more keywords
IGF2BP1 promotes LPS-induced NFκB activation and pro-inflammatory cytokines production in human macrophages and monocytes.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.03.206
Abstract: BACKGROUND Lipopolysaccharide (LPS)-induced macrophage/monocyte activation and pro-inflammatory cytokines production are important mediators for periodontitis progression. The current study tested the potential role of insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in the process. METHODS THP-1… read more here.
Keywords: production; lps induced; inflammatory cytokines; activation ... See more keywords
Chitinase 3-like-1 and fibronectin in the cargo of extracellular vesicles shed by human macrophages influence pancreatic cancer cellular response to gemcitabine.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer letters"
DOI: 10.1016/j.canlet.2020.11.013
Abstract: Tumour-associated macrophages have been implicated in pancreatic ductal adenocarcinoma (PDAC) therapy response and Extracellular vesicles (EVs) shed by macrophages might have a role in this process. Here, we demonstrated that large EVs released by anti-inflammatory… read more here.
Keywords: extracellular vesicles; response; gemcitabine; chi3l1 fn1 ... See more keywords
Corneal tissue induces transcription of metallothioneins in monocyte-derived human macrophages.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular immunology"
DOI: 10.1016/j.molimm.2020.10.016
Abstract: PURPOSE Immune reactions following corneal transplantation are the most common cause of transplant failure. However, the underlying mechanisms of corneal graft rejection are not yet fully understood but increasing evidence points to a crucial role… read more here.
Keywords: corneal tissue; tissue; mdms; human macrophages ... See more keywords
Synergistic interactions of chamomile flower, myrrh and coffee charcoal in inhibiting pro-inflammatory chemokine release from activated human macrophages
Sign Up to like & getrecommendations! Published in 2017 at "Synergy"
DOI: 10.1016/j.synres.2017.03.001
Abstract: Abstract Background The herbal medicinal product Myrrhinil-Intest®, a combination of myrrh, chamomile flower extract and coffee charcoal is used for the maintenance therapy of inflammatory bowel disease. In vitro studies revealed that the herbal components… read more here.
Keywords: chamomile flower; coffee; coffee charcoal; human macrophages ... See more keywords
ATHEROPROTECTIVE ACTIONS OF OXYTOCIN IN HUMAN MACROPHAGES: REDUCED LIPID ACCUMULATION UNDER INFLAMMATORY CONDITIONS
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(19)32666-x
Abstract: Oxytocin (OT) is a neuropeptide hormone secreted by the posterior pituitary gland physiologically associated with parturition, lactation, and other reproductive functions, and psychologically associated with affiliative behavior and anxiolytic effects. Deficits in OT action have… read more here.
Keywords: atheroprotective actions; reduced lipid; human macrophages; oxytocin human ... See more keywords
Triclosan Reprograms Immunometabolism and Activates the Inflammasome in Human Macrophages.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental science & technology"
DOI: 10.1021/acs.est.2c05254
Abstract: To gather enough energy to respond to harmful stimuli, most immune cells quickly shift their metabolic profile. This process of immunometabolism plays a critical role in the regulation of immune cell function. Triclosan, a synthetic… read more here.
Keywords: immunometabolism; triclosan reprograms; immunometabolism activates; reprograms immunometabolism ... See more keywords