Controlled Human Malaria Infection (CHMI) Studies: Over 100 Years of Experience with Parasite Injections.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9550-9_7
Abstract: Human experimentation by deliberate infection with malarial parasites seems unethical yet has a long history in infectious disease research. After rigorous screening, volunteers are inoculated with Plasmodium sporozoites or blood stages and monitored under strict… read more here.
Keywords: controlled human; infection; malaria infection; chmi studies ... See more keywords
Evolution of human malaria
Sign Up to like & getrecommendations! Published in 2018 at "Nature Microbiology"
DOI: 10.1038/s41564-018-0170-2
Abstract: Comparative genomics of all known Laverania species that infect African great apes reveals interspecies gene transfer and convergent evolution, and identifies features of Plasmodium falciparum, the only human-infective species within this subgenus, that may have… read more here.
Keywords: microbiology; human malaria; evolution human; evolution ... See more keywords
An Exported Kinase Family Mediates Species-Specific Erythrocyte Remodelling and Virulence in Human Malaria
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DOI: 10.1038/s41564-020-0702-4
Abstract: The most severe form of human malaria is caused by Plasmodium falciparum . Its virulence is closely linked to the increase in rigidity of infected erythrocytes and their adhesion to endothelial receptors, obstructing blood flow… read more here.
Keywords: virulence; family; species specific; exported kinase ... See more keywords
The human malaria parasite Plasmodium falciparum can sense environmental changes and respond by antigenic switching.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2302152120
Abstract: The primary antigenic and virulence determinant of the human malaria parasite Plasmodium falciparum is a variant surface protein called PfEMP1. Different forms of PfEMP1 are encoded by a multicopy gene family called var, and switching… read more here.
Keywords: malaria parasite; expression; falciparum; human malaria ... See more keywords
Epigenetic reader complexes of the human malaria parasite, Plasmodium falciparum
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz1044
Abstract: Abstract Epigenetic regulatory mechanisms are central to the development and survival of all eukaryotic organisms. These mechanisms critically depend on the marking of chromatin domains with distinctive histone tail modifications (PTMs) and their recognition by… read more here.
Keywords: complexes human; reader; reader complexes; plasmodium falciparum ... See more keywords
Controlled human malaria infection with a clone of Plasmodium vivax with high quality genome assembly.
Sign Up to like & getrecommendations! Published in 2021 at "JCI insight"
DOI: 10.1172/jci.insight.152465
Abstract: Controlled human malaria infection (CHMI) provides a highly informative means to investigate host-pathogen interactions and enable in vivo proof-of-concept efficacy testing of new drugs and vaccines. However, unlike Plasmodium falciparum, well-characterized P. vivax parasites that… read more here.
Keywords: controlled human; high quality; quality genome; vivax ... See more keywords
Platelets kill circulating parasites of all major Plasmodium species in human malaria.
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-05-849307
Abstract: Platelets are understood to assist host innate immune responses against infection, although direct evidence of this function in any human disease, including malaria, is unknown. Here we characterized platelet-erythrocyte interactions by microscopy and flow cytometry… read more here.
Keywords: plasmodium species; parasite killing; circulating parasites; plasmodium ... See more keywords
Refining the transcriptome of the human malaria parasite Plasmodium falciparum using amplification-free RNA-seq
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DOI: 10.1186/s12864-020-06787-5
Abstract: Plasmodium parasites undergo several major developmental transitions during their complex lifecycle, which are enabled by precisely ordered gene expression programs. Transcriptomes from the 48-h blood stages of the major human malaria parasite Plasmodium falciparum have… read more here.
Keywords: malaria parasite; falciparum; plasmodium; human malaria ... See more keywords
Rapid antigen diversification through mitotic recombination in the human malaria parasite Plasmodium falciparum
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DOI: 10.1371/journal.pbio.3000271
Abstract: Malaria parasites possess the remarkable ability to maintain chronic infections that fail to elicit a protective immune response, characteristics that have stymied vaccine development and cause people living in endemic regions to remain at risk… read more here.
Keywords: diversity; recombination; plasmodium falciparum; antigen ... See more keywords
The Power of Malaria Vaccine Trials Using Controlled Human Malaria Infection
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DOI: 10.1371/journal.pcbi.1005255
Abstract: Controlled human malaria infection (CHMI) in healthy human volunteers is an important and powerful tool in clinical malaria vaccine development. However, power calculations are essential to obtain meaningful estimates of protective efficacy, while minimizing the… read more here.
Keywords: vaccine trials; controlled human; power; malaria infection ... See more keywords
A novel PCR-based system for the detection of four species of human malaria parasites and Plasmodium knowlesi
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0191886
Abstract: A microscopy-based diagnosis is the gold standard for the detection and identification of malaria parasites in a patient’s blood. However, the detection of cases involving a low number of parasites and the differentiation of species… read more here.
Keywords: detection; pcr; malaria parasites; human malaria ... See more keywords