The multidimensional role of the Wnt/β-catenin signaling pathway in human malignancies.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30561
Abstract: Several signaling pathways have been identified as important for developmental processes. One of such important cascades is the Wnt/β-catenin signaling pathway, which can regulate various physiological processes such as embryonic development, tissue homeostasis, and tissue… read more here.
Keywords: catenin signaling; catenin; signaling pathway; human malignancies ... See more keywords
FEZF1-AS1: a novel vital oncogenic lncRNA in multiple human malignancies
Sign Up to like & getrecommendations! Published in 2019 at "Bioscience Reports"
DOI: 10.1042/bsr20191202
Abstract: Long noncoding RNAs (LncRNAs) refer to the RNA with a length of >200 nucleotides, which lack or have no open reading coding frame and have higher tissue and organ specificity compared with the protein coding… read more here.
Keywords: human malignancies; oncogenic lncrna; vital oncogenic; novel vital ... See more keywords
Ponatinib: a novel multi-tyrosine kinase inhibitor against human malignancies
Sign Up to like & getrecommendations! Published in 2019 at "OncoTargets and therapy"
DOI: 10.2147/ott.s189391
Abstract: Human malignancies are often the result of overexpressed and constitutively active receptor and non-receptor tyrosine kinases, which ultimately lead to the mediation of key tumor-driven pathways. Several tyrosine kinases (ie, EGFR, FGFR, PDGFR, VEGFR), are… read more here.
Keywords: human malignancies; multi tyrosine; tyrosine kinase; kinase inhibitor ... See more keywords
AR Signaling in Human Malignancies: Prostate Cancer and Beyond
Sign Up to like & getrecommendations! Published in 2018 at "Cancers"
DOI: 10.3390/cancers10010022
Abstract: The notion that androgens and androgen receptor (AR) signaling are the hallmarks of prostate cancer oncogenesis and disease progression is generally well accepted. What is more poorly understood is the role of AR signaling in… read more here.
Keywords: malignancies prostate; prostate cancer; human malignancies; cancer beyond ... See more keywords
Role of Telomeres and Telomeric Proteins in Human Malignancies and Their Therapeutic Potential
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DOI: 10.3390/cancers12071901
Abstract: Telomeres are the ends of linear chromosomes comprised of repetitive nucleotide sequences in humans. Telomeres preserve chromosomal stability and genomic integrity. Telomere length shortens with every cell division in somatic cells, eventually resulting in replicative… read more here.
Keywords: role telomeres; human malignancies; role; telomeric proteins ... See more keywords
Dysregulation of the Ubiquitin Proteasome System in Human Malignancies: A Window for Therapeutic Intervention
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DOI: 10.3390/cancers13071513
Abstract: Simple Summary The ubiquitin proteasome system (UPS) governs the non-lysosomal degradation of oxidized, damaged, or misfolded proteins in eukaryotic cells. Dysregulation of the UPS results in loss of ability to maintain protein quality through proteolysis,… read more here.
Keywords: proteasome; dysregulation; proteasome system; human malignancies ... See more keywords
ABHD11-AS1: An Emerging Long Non-Coding RNA (lncRNA) with Clinical Significance in Human Malignancies
Sign Up to like & getrecommendations! Published in 2022 at "Non-Coding RNA"
DOI: 10.3390/ncrna8020021
Abstract: The aberrant expression of lncRNAs has been linked to the development and progression of different cancers. One such lncRNA is ABHD11 antisense RNA 1 (ABHD11-AS1), which has recently gained attention for its significant role in… read more here.
Keywords: human malignancies; clinical significance; rna; abhd11 as1 ... See more keywords