iTRAQ‐based proteomic and bioinformatic characterization of human mast cells upon infection by the influenza A virus strains H1N1 and H5N1
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13523
Abstract: Mast cells can support the replication of influenza A virus, although how this occurs is poorly understood. In the present study, using quantitative MS, we analyzed the proteome of human mast cells infected with different… read more here.
Keywords: mast cells; infection; human mast; influenza virus ... See more keywords
Selective immunocapture reveals neoplastic human mast cells secrete distinct microvesicle‐ and exosome‐like populations of KIT‐containing extracellular vesicles
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12272
Abstract: Abstract Activating mutations in the receptor KIT promote the dysregulated proliferation of human mast cells (huMCs). The resulting neoplastic huMCs secrete extracellular vesicles (EVs) that can transfer oncogenic KIT among other cargo into recipient cells.… read more here.
Keywords: human mast; immunocapture; extracellular vesicles; kit ... See more keywords
Innate defense regulator IDR-1018 activates human mast cells through G protein-, phospholipase C-, MAPK- and NF-ĸB-sensitive pathways
Sign Up to like & getrecommendations! Published in 2017 at "Immunologic Research"
DOI: 10.1007/s12026-017-8932-0
Abstract: Host defense (antimicrobial) peptides not only display antimicrobial activities against numerous pathogens but also exert a broader spectrum of immune-modulating functions. Innate defense regulators (IDRs) are a class of host defense peptides synthetically developed from… read more here.
Keywords: defense; mast cells; idr 1018; mast ... See more keywords
Self-Assembling Peptide Nanoscaffold That Activates Human Mast Cells.
Sign Up to like & getrecommendations! Published in 2018 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.7b14560
Abstract: Engineering biomaterials to manipulate the immune response to elicit specific therapeutic outcomes is a burgeoning field of research. Mast cells play a distinct and central role in the innate immune response, and are characterized by… read more here.
Keywords: self assembling; mast cells; mast; human mast ... See more keywords
Rapid identification of human mast cell degranulation regulators using functional genomics coupled to high-resolution confocal microscopy
Sign Up to like & getrecommendations! Published in 2020 at "Nature protocols"
DOI: 10.1038/s41596-019-0288-6
Abstract: Targeted functional genomics represents a powerful approach for studying gene function in vivo and in vitro. However, its application to gene expression studies in human mast cells has been hampered by low yields of human… read more here.
Keywords: degranulation; microscopy; mast; human mast ... See more keywords
Human Mast Cell Sensitization with IgE Increases miRNA-210 Expression
Sign Up to like & getrecommendations! Published in 2019 at "International Archives of Allergy and Immunology"
DOI: 10.1159/000496513
Abstract: Background: MicroRNAs (miRNAs) represent important post-transcriptional regulators with a dynamic expression profile during health and disease. Objectives: We explored the miRNA profile of human mast cells (MCs) during sensitization with IgE, during activation through IgE,… read more here.
Keywords: ige; human mast; expression; mirna 210 ... See more keywords
Human mast cells release the migraine-inducing factor pituitary adenylate cyclase-activating polypeptide (PACAP)
Sign Up to like & getrecommendations! Published in 2018 at "Cephalalgia"
DOI: 10.1177/0333102417740563
Abstract: Background Many patients with migraines suffer from allergies and vice versa, suggesting a relationship between biological mechanisms of allergy and migraine. It was proposed many years ago that mast cells may be involved in the… read more here.
Keywords: mast cells; mast; pacap; pituitary adenylate ... See more keywords
A Critical Function for the Transcription Factors GLI1 and GLI2 in the Proliferation and Survival of Human Mast Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.841045
Abstract: Mast cell hyperactivity and accumulation in tissues are associated with allergy and other mast cell-related disorders. However, the molecular pathways regulating mast cell survival in homeostasis and disease are not completely understood. As glioma-associated oncogene… read more here.
Keywords: human mast; mast; proliferation; mast cells ... See more keywords
Heterogeneity of Human Mast Cells With Respect to MRGPRX2 Receptor Expression and Function
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2019.00299
Abstract: Mast cells and their mediators play a role in the control of homeostasis and in the pathogenesis of several disorders. The concept of rodent mast cell heterogeneity, initially established in the mid-1960s has been extended… read more here.
Keywords: mast cells; mast; human mast; hlmcs ... See more keywords