Understanding the Species Selectivity of Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00626
Abstract: To test for on target toxicity of a new chemical entity, it is important to have comparable binding affinities of the compound in the target proteins from humans and the test species. To evaluate our… read more here.
Keywords: mcl; affinity; mcl inhibitors; myeloid cell ... See more keywords
Human MCL forms a heteromeric receptor complex with Mincle but not Dectin-2.
Sign Up to like & getrecommendations! Published in 2022 at "Scandinavian journal of immunology"
DOI: 10.1111/sji.13149
Abstract: MCL, Mincle and Dectin-2 are C-type lectin receptors expressed by subsets of myeloid cells, and their genes cluster together in the APLEC/Dectin-2 gene complex. We have previously shown that MCL and Mincle form a heterodimer… read more here.
Keywords: human mcl; mcl mincle; mcl; mincle ... See more keywords