Abstract 2978: The utilization of a human MCL1 knockin mouse suggests that reductions in B-cells and monocytes may serve as clinically relevant pharmacodynamic markers of MCL1 inhibition
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DOI: 10.1158/1538-7445.am2018-2978
Abstract: The development of small-molecule inhibitors targeting pro-survival BCL-2 family members, such as MCL1 and BCL-2, is an attractive approach for the treatment of cancer. AMG 176 is a potent and selective first-in-class MCL1 inhibitor currently… read more here.
Keywords: mcl1 knockin; amg 176; human mcl1; mcl1 ... See more keywords