Suppressing ROS‐TFE3‐dependent autophagy enhances ivermectin‐induced apoptosis in human melanoma cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27490
Abstract: Melanoma is an aggressive skin malignancy with a high mortality rate; however, successful treatment remains a clinical challenge. Ivermectin, a broad‐spectrum antiparasitic drug, has recently been characterized as a potential anticancer agent due to its… read more here.
Keywords: apoptosis; ivermectin induced; autophagy; ivermectin ... See more keywords
Regulation of miR‐21 expression in human melanoma via UV‐ray‐induced melanin pigmentation
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Toxicology"
DOI: 10.1002/tox.22421
Abstract: Excessive environmental ultraviolet (UV) radiation produces genetic mutations that can lead to skin cancer. This study was designed to assess the potential inhibitory activity of microRNA‐21 (miR‐21) on the UV irradiation‐stimulated melanogenesis signal pathway in… read more here.
Keywords: ray induced; mir; expression; ray ... See more keywords
Melanoma tumour vasculature heterogeneity: from mice models to human
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-018-2809-z
Abstract: Tumour angiogenesis is defined by an anarchic vasculature and irregularities in alignment of endothelial cells. These structural abnormalities could explain the variability in distribution of nanomedicines in various tumour models. Then, the main goal of… read more here.
Keywords: melanoma; vasculature; melanoma models; mice ... See more keywords
Timosaponin AIII induces apoptosis and autophagy in human melanoma A375-S2 cells
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Pharmacal Research"
DOI: 10.1007/s12272-016-0763-3
Abstract: Timosaponin AIII (AIII), a steroidal saponin isolated from Anemarrhena asphodeloides Bge. Our study showed that AIII induced both apoptosis and autophagy, and autophagy inhibited apoptosis in A375S2 cells. Furtherly, this study was carried out to… read more here.
Keywords: apoptosis autophagy; timosaponin aiii; aiii induces; autophagy human ... See more keywords
Depigmenting effect of Xanthohumol from hop extract in MNT-1 human melanoma cells and normal human melanocytes
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2021.100955
Abstract: Xanthohumol (XH) is the most abundant prenylated flavonoid found in the hop plant (Humulus lupulus L.) and has previously been shown to have depigmenting effects in B16F10 mouse melanoma cells; however, studies of its depigmenting… read more here.
Keywords: export; mnt human; melanoma cells; human melanocytes ... See more keywords
Knockdown of circ_0084043 suppresses the development of human melanoma cells through miR-429/tribbles homolog 2 axis and Wnt/β-catenin pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117323
Abstract: AIMS Circular RNAs (circRNAs) have been emerged as novel regulators in multiple tumorigenesis, including melanoma. CircRNA_0084043 was recently demonstrated to be deregulated in human melanoma cells. Nevertheless, its role and mechanism are largely unrevealed in… read more here.
Keywords: melanoma; mir 429; catenin; circ 0084043 ... See more keywords
Development of efficient adeno-associated virus (AAV)-mediated gene delivery system with a phytoactive material for targeting human melanoma cells.
Sign Up to like & getrecommendations! Published in 2017 at "New biotechnology"
DOI: 10.1016/j.nbt.2017.02.001
Abstract: We exploited the emerging potential of gene therapy strategies to design a powerful therapeutic system that combines two key components-AAV vector and [6]-gingerol. In this study, we created an AAV2 construct expressing the proapoptotic protein… read more here.
Keywords: melanoma; system; melanoma cells; gene ... See more keywords
Piperlongumine Induces Apoptosis in Human Melanoma Cells Via Reactive Oxygen Species Mediated Mitochondria Disruption
Sign Up to like & getrecommendations! Published in 2018 at "Nutrition and Cancer"
DOI: 10.1080/01635581.2018.1445769
Abstract: ABSTRACT Malignant melanoma is a devastating skin cancer due to its severe drug resistance and prompt metastasis. Piperlongumine is an anti-inflammation and tumor-suppressing natural product with defined structure. While numerous studies revealed exceptional inhibitory effects… read more here.
Keywords: melanoma; reactive oxygen; oxygen species; melanoma cells ... See more keywords
Acridine Orange/exosomes increase the delivery and the effectiveness of Acridine Orange in human melanoma cells: A new prototype for theranostics of tumors
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2017.1292263
Abstract: Abstract Specifically targeted drug delivery systems with low immunogenicity and toxicity are deemed to increase efficacy of cancer chemotherapy. Acridine Orange (AO) is an acidophilic dye with a strong tumoricidal action following excitation with a… read more here.
Keywords: delivery; melanoma cells; acridine orange; orange ... See more keywords
Noncalcemic 20-hydroxyvitamin D3 inhibits human melanoma growth in in vitro and in vivo models
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14193
Abstract: A novel pathway of vitamin D3 (D3) metabolism, initiated by C20-hydroxylation of D3 by CYP11A1, has been confirmed to operate in vivo. Its major product, 20(OH)D3, exhibits antiproliferative activity in vitro comparable to that of… read more here.
Keywords: melanoma; human melanoma; vivo; hydroxyvitamin inhibits ... See more keywords
Oncolytic Tanapoxvirus Expressing Interleukin-2 is Capable of Inducing the Regression of Human Melanoma Tumors in the Absence of T Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Current cancer drug targets"
DOI: 10.2174/1568009617666170630143931
Abstract: BACKGROUND Oncolytic viruses (OVs), which preferentially infect cancer cells and induce host anti-tumor immune responses, have emerged as an effective melanoma therapy. Tanapoxvirus (TANV), which possesses a large genome and causes mild self-limiting disease in… read more here.
Keywords: tanv 66r; human melanoma; mil; 66r mil ... See more keywords