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   Articles with "human melanoma" as a keyword



Suppressing ROS‐TFE3‐dependent autophagy enhances ivermectin‐induced apoptosis in human melanoma cells

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recommendations! Published in 2018 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.27490

Abstract: Melanoma is an aggressive skin malignancy with a high mortality rate; however, successful treatment remains a clinical challenge. Ivermectin, a broad‐spectrum antiparasitic drug, has recently been characterized as a potential anticancer agent due to its… read more here.

Keywords: apoptosis; ivermectin induced; autophagy; ivermectin ... See more keywords

Regulation of miR‐21 expression in human melanoma via UV‐ray‐induced melanin pigmentation

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recommendations! Published in 2017 at "Environmental Toxicology"

DOI: 10.1002/tox.22421

Abstract: Excessive environmental ultraviolet (UV) radiation produces genetic mutations that can lead to skin cancer. This study was designed to assess the potential inhibitory activity of microRNA‐21 (miR‐21) on the UV irradiation‐stimulated melanogenesis signal pathway in… read more here.

Keywords: ray induced; mir; expression; ray ... See more keywords

Fucoxanthin induces human melanoma cytotoxicity by thwarting the JAK2/STAT3/BCL‐xL signaling axis

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recommendations! Published in 2024 at "Environmental Toxicology"

DOI: 10.1002/tox.24193

Abstract: Melanoma is the most lethal skin malignancy. Fucoxanthin is a marine carotenoid with significant anticancer activities. Intriguingly, Fucoxanthin's impact on human melanoma remains elusive. Signal Transducer and Activator of Transcription 3 (STAT3) represents a promising… read more here.

Keywords: bcl; melanoma; human melanoma; melanoma cytotoxicity ... See more keywords

Melanoma tumour vasculature heterogeneity: from mice models to human

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recommendations! Published in 2018 at "Journal of Cancer Research and Clinical Oncology"

DOI: 10.1007/s00432-018-2809-z

Abstract: Tumour angiogenesis is defined by an anarchic vasculature and irregularities in alignment of endothelial cells. These structural abnormalities could explain the variability in distribution of nanomedicines in various tumour models. Then, the main goal of… read more here.

Keywords: melanoma; vasculature; melanoma models; mice ... See more keywords

Timosaponin AIII induces apoptosis and autophagy in human melanoma A375-S2 cells

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recommendations! Published in 2017 at "Archives of Pharmacal Research"

DOI: 10.1007/s12272-016-0763-3

Abstract: Timosaponin AIII (AIII), a steroidal saponin isolated from Anemarrhena asphodeloides Bge. Our study showed that AIII induced both apoptosis and autophagy, and autophagy inhibited apoptosis in A375S2 cells. Furtherly, this study was carried out to… read more here.

Keywords: apoptosis autophagy; timosaponin aiii; aiii induces; autophagy human ... See more keywords
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Depigmenting effect of Xanthohumol from hop extract in MNT-1 human melanoma cells and normal human melanocytes

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recommendations! Published in 2021 at "Biochemistry and Biophysics Reports"

DOI: 10.1016/j.bbrep.2021.100955

Abstract: Xanthohumol (XH) is the most abundant prenylated flavonoid found in the hop plant (Humulus lupulus L.) and has previously been shown to have depigmenting effects in B16F10 mouse melanoma cells; however, studies of its depigmenting… read more here.

Keywords: export; mnt human; melanoma cells; human melanocytes ... See more keywords

Knockdown of circ_0084043 suppresses the development of human melanoma cells through miR-429/tribbles homolog 2 axis and Wnt/β-catenin pathway.

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recommendations! Published in 2020 at "Life sciences"

DOI: 10.1016/j.lfs.2020.117323

Abstract: AIMS Circular RNAs (circRNAs) have been emerged as novel regulators in multiple tumorigenesis, including melanoma. CircRNA_0084043 was recently demonstrated to be deregulated in human melanoma cells. Nevertheless, its role and mechanism are largely unrevealed in… read more here.

Keywords: melanoma; mir 429; catenin; circ 0084043 ... See more keywords

Development of efficient adeno-associated virus (AAV)-mediated gene delivery system with a phytoactive material for targeting human melanoma cells.

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recommendations! Published in 2017 at "New biotechnology"

DOI: 10.1016/j.nbt.2017.02.001

Abstract: We exploited the emerging potential of gene therapy strategies to design a powerful therapeutic system that combines two key components-AAV vector and [6]-gingerol. In this study, we created an AAV2 construct expressing the proapoptotic protein… read more here.

Keywords: melanoma; system; melanoma cells; gene ... See more keywords

Impairing hydrolase transport machinery prevents human melanoma metastasis

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recommendations! Published in 2024 at "Communications Biology"

DOI: 10.1038/s42003-024-06261-y

Abstract: Metastases are the major cause of cancer-related death, yet, molecular weaknesses that could be exploited to prevent tumor cells spreading are poorly known. Here, we found that perturbing hydrolase transport to lysosomes by blocking either… read more here.

Keywords: hydrolase transport; human melanoma; metastasis; hydrolase ... See more keywords

Piperlongumine Induces Apoptosis in Human Melanoma Cells Via Reactive Oxygen Species Mediated Mitochondria Disruption

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recommendations! Published in 2018 at "Nutrition and Cancer"

DOI: 10.1080/01635581.2018.1445769

Abstract: ABSTRACT Malignant melanoma is a devastating skin cancer due to its severe drug resistance and prompt metastasis. Piperlongumine is an anti-inflammation and tumor-suppressing natural product with defined structure. While numerous studies revealed exceptional inhibitory effects… read more here.

Keywords: melanoma; reactive oxygen; oxygen species; melanoma cells ... See more keywords

Acridine Orange/exosomes increase the delivery and the effectiveness of Acridine Orange in human melanoma cells: A new prototype for theranostics of tumors

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recommendations! Published in 2017 at "Journal of Enzyme Inhibition and Medicinal Chemistry"

DOI: 10.1080/14756366.2017.1292263

Abstract: Abstract Specifically targeted drug delivery systems with low immunogenicity and toxicity are deemed to increase efficacy of cancer chemotherapy. Acridine Orange (AO) is an acidophilic dye with a strong tumoricidal action following excitation with a… read more here.

Keywords: delivery; melanoma cells; acridine orange; orange ... See more keywords