Signatures of TSPAN8 variants associated with human metabolic regulation and diseases
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DOI: 10.1016/j.isci.2021.102893
Abstract: Summary Here, with the example of common copy number variation (CNV) in the TSPAN8 gene, we present an important piece of work in the field of CNV detection, that is, CNV association with complex human… read more here.
Keywords: human metabolic; associated human; tspan8 variants; signatures tspan8 ... See more keywords
Plasma Sphingolipidome as a Surrogate for Human Metabolic Heath.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2017.10.109
Abstract: In a recent issue of the Journal , Caleyachetty et al. [(1)][1] demonstrated that metabolically healthy obese (MHO) individuals are at higher risk of coronary heart disease, cerebrovascular disease, and heart failure than normal weight metabolically… read more here.
Keywords: plasma sphingolipidome; human metabolic; surrogate human; cardiology ... See more keywords
SRC-2 Coactivator: a role in human metabolic evolution and disease
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Medicine"
DOI: 10.1186/s10020-020-00168-0
Abstract: The large family of transcriptional coactivators originated with the cloning of the subfamily of Steroid Receptor Coactivators (SRC-1,2,3). These 3 coactivators serve as primary ‘master genes’ to direct the coordinate transcription of multiple genes required… read more here.
Keywords: human metabolic; evolution disease; role human; coactivator role ... See more keywords
Identification of cardiomyopathy-related core genes through human metabolic networks and expression data
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DOI: 10.1186/s12864-021-08271-0
Abstract: Background Cardiomyopathy is a complex type of myocardial disease, and its incidence has increased significantly in recent years. Dilated cardiomyopathy (DCM) and ischemic cardiomyopathy (ICM) are two common and indistinguishable types of cardiomyopathy. Results Here,… read more here.
Keywords: related core; human metabolic; core genes; cardiomyopathy related ... See more keywords
The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers
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DOI: 10.1186/s12935-021-01799-x
Abstract: The human insulin-like growth factor 2 (IGF2) mRNA binding proteins 2 (IGF2BP2/IMP2) is an RNA-binding protein that regulates multiple biological processes. Previously, IGF2BP2 was thought to be a type 2 diabetes (T2D)-associated gene. Indeed IGF2BP2… read more here.
Keywords: human metabolic; igf2bp2; metabolic diseases; m6a reader ... See more keywords
In Silico and In Vitro Tailoring of a Chitosan Nanoformulation of a Human Metabolic Enzyme
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DOI: 10.3390/pharmaceutics13030329
Abstract: Enzyme nanoencapsulation holds an enormous potential to develop new therapeutic approaches to a large set of human pathologies including cancer, infectious diseases and inherited metabolic disorders. However, enzyme formulation has been limited by the need… read more here.
Keywords: human metabolic; tailoring chitosan; vitro tailoring; silico vitro ... See more keywords