Chemogenomic Profiling of Human and Microbial FK506-Binding Proteins.
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DOI: 10.1021/acs.jmedchem.8b00137
Abstract: FK506-binding proteins (FKBPs) are evolutionarily conserved proteins that display peptidyl-prolyl isomerase activities and act as coreceptors for immunosuppressants. Microbial macrophage-infectivity-potentiator (Mip)-type FKBPs can enhance infectivity. However, developing druglike ligands for FKBPs or Mips has proven… read more here.
Keywords: binding proteins; chemogenomic profiling; fk506 binding; profiling human ... See more keywords
MiMeDB: the Human Microbial Metabolome Database
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac868
Abstract: Abstract The Human Microbial Metabolome Database (MiMeDB) (https://mimedb.org) is a comprehensive, multi-omic, microbiome resource that connects: (i) microbes to microbial genomes; (ii) microbial genomes to microbial metabolites; (iii) microbial metabolites to the human exposome and… read more here.
Keywords: mimedb; metabolome database; database; microbial metabolome ... See more keywords
Altered Fecal Small RNA Profiles in Colorectal Cancer Reflect Gut Microbiome Composition in Stool Samples
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DOI: 10.1128/msystems.00289-19
Abstract: The characteristics of microbial small RNA transcription are largely unknown, while it is of primary importance for a better identification of molecules with functional activities in the gut niche under both healthy and disease conditions.… read more here.
Keywords: small rna; human microbial; stool samples; microbial small ... See more keywords
Gooey Gut Trail: Board Game Play to Understand Human-Microbial Interactions
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the ACM on Human-Computer Interaction"
DOI: 10.1145/3549502
Abstract: Our gastrointestinal health is influenced by complex interactions between our gut bacteria and multiple external factors. A wider understanding of these concepts is vital to help make gut-friendly decisions in everyday life; however, its complexity… read more here.
Keywords: board game; gooey gut; gut trail; game ... See more keywords
Inhibitory Effects of Quercetin and Its Human and Microbial Metabolites on Xanthine Oxidase Enzyme
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DOI: 10.3390/ijms20112681
Abstract: Quercetin is an abundant flavonoid in nature and is used in several dietary supplements. Although quercetin is extensively metabolized by human enzymes and the colonic microflora, we have only few data regarding the pharmacokinetic interactions… read more here.
Keywords: xanthine oxidase; inhibitory effects; microbial metabolites; enzyme inhibitory ... See more keywords