Human microdosing and mice xenograft data of AGM-130 applied to estimate efficacious doses in patients
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-017-3373-y
Abstract: PurposeAGM-130 is a cyclin-dependent kinase inhibitor that exhibits dose-dependent efficacy in xenograft mouse models. During preclinical pharmacokinetic (PK) studies, mice and rats showed comparable PK parameters while dogs showed unusually high clearance (CL), which has… read more here.
Keywords: human microdosing; xenograft; agm 130; model ... See more keywords