Transnasal transplantation of human induced pluripotent stem cell‐derived microglia to the brain of immunocompetent mice
Sign Up to like & getrecommendations! Published in 2021 at "Glia"
DOI: 10.1002/glia.23985
Abstract: Microglia are the resident immune cells of the brain, and play essential roles in neuronal development, homeostatic function, and neurodegenerative disease. Human microglia are relatively different from mouse microglia. However, most research on human microglia… read more here.
Keywords: cell derived; human microglia; stem cell; induced pluripotent ... See more keywords
Stimuli-Responsive Miktoarm Polymer-Based Formulations for Fisetin Delivery and Regulatory Effects in Hyperactive Human Microglia.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202200174
Abstract: Branched star polymers offer exciting opportunities in enhancing the efficacy of nanocarriers in delivering biologically active lipophilic agents. We demonstrate that the star polymeric architecture can be leveraged to yield soft nanoparticles of vesicular morphology… read more here.
Keywords: stimuli responsive; miktoarm polymer; human microglia; microglia ... See more keywords
Insights into the Impact of Gold Nanoclusters Au10SG10 on Human Microglia.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00621
Abstract: The purpose of the current study is to uncover the impact of small liganded gold nanoclusters with 10 gold atoms and 10 glutathione ligands (Au10SG10) on several biomarkers in human microglia. We established the links… read more here.
Keywords: nanoclusters au10sg10; gold nanoclusters; insights impact; au10sg10 human ... See more keywords
Transcriptional landscape of human microglia implicates age, sex, and APOE‐related immunometabolic pathway perturbations
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13606
Abstract: Microglia have fundamental roles in health and disease; however, effects of age, sex, and genetic factors on human microglia have not been fully explored. We applied bulk and single‐cell approaches to comprehensively characterize human microglia… read more here.
Keywords: human microglia; age sex; sex apoe; age ... See more keywords
An environment-dependent transcriptional network specifies human microglia identity
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.aal3222
Abstract: Of mice and men's microglia Microglia are immune system cells that function in protecting and maintaining the brain. Gosselin et al. examined the epigenetics and RNA transcripts from single microglial cells and observed consistent profiles… read more here.
Keywords: human microglia; gene expression; brain; expression ... See more keywords
New models of Parkinson’s like neuroinflammation in human microglia clone 3: Activation profiles induced by INF-γ plus high glucose and mitochondrial inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.1038721
Abstract: Microglia activation and neuroinflammation have been extensively studied in murine models of neurodegenerative diseases; however, to overcome the genetic differences between species, a human cell model of microglia able to recapitulate the activation profiles described… read more here.
Keywords: models parkinson; parkinson like; like neuroinflammation; human microglia ... See more keywords
Proficiency of Extracellular Vesicles From hiPSC-Derived Neural Stem Cells in Modulating Proinflammatory Human Microglia: Role of Pentraxin-3 and miRNA-21-5p
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.845542
Abstract: Extracellular vesicles (EVs) shed by human-induced pluripotent stem cell (hiPSC)-derived neural stem cells (hNSC-EVs) have shown potent antiinflammatory properties in a mouse macrophage assay and a mouse model of acute neuroinflammation. They can also quickly… read more here.
Keywords: proficiency; hnsc evs; proinflammatory human; human microglia ... See more keywords
Human Microglia Synthesize Neurosteroids to Cope with Rotenone-Induced Oxidative Stress
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12040963
Abstract: We obtained evidence that mouse BV2 microglia synthesize neurosteroids dynamically to modify neurosteroid levels in response to oxidative damage caused by rotenone. Here, we evaluated whether neurosteroids could be produced and altered in response to… read more here.
Keywords: microglia synthesize; synthesize neurosteroids; oxidative stress; human microglia ... See more keywords
Pro-Inflammatory Activation of a New Immortalized Human Microglia Cell Line
Sign Up to like & getrecommendations! Published in 2019 at "Brain Sciences"
DOI: 10.3390/brainsci9050111
Abstract: The characterization of human microglia has been hampered by poor availability of human cell sources. However, microglia is involved in the physiopathology of multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, HIV dementia, retinal degenerative diseases, cancer,… read more here.
Keywords: human microglia; cell line; cell; immortalized human ... See more keywords