Exploitation of microRNAs by Japanese Encephalitis virus in human microglial cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medical Virology"
DOI: 10.1002/jmv.24995
Abstract: JEV infection in CNS leads to the JE neuroinflammation. Children and old age individual have been reported to be more prone to JEV infection. MicroRNAs are endogenous, small non‐coding RNAs, which regulate the gene expression.… read more here.
Keywords: human microglial; exploitation micrornas; micrornas japanese; japanese encephalitis ... See more keywords
Tp47 induces cell death involving autophagy and mTOR in human microglial HMO6 cells.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.04.013
Abstract: BACKGROUND Tp47 can induce immune cells to produce numerous inflammatory factors, some of which can trigger autophagy. Increased autophagy has a dual effect on cell survival. However, whether Tp47 induces autophagy in microglia is unknown.… read more here.
Keywords: death; human microglial; hmo6; cell death ... See more keywords
Alzheimer's Amyloid-β Accelerates Cell Senescence and Suppresses the SIRT1/NRF2 Pathway in Human Microglial Cells
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/3086010
Abstract: Microglia play important roles in maintenance of brain homeostasis, while due to some pathological stimuli in aging-related neurodegenerative diseases including Alzheimer's disease, they are malfunctioning. Here, we demonstrated that amyloid-β (Aβ) accelerated cell senescence characterized… read more here.
Keywords: human microglial; sirt1 nrf2; microglial cells; senescence ... See more keywords
Erythropoietin Enhances Post-ischemic Migration and Phagocytosis and Alleviates the Activation of Inflammasomes in Human Microglial Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.915348
Abstract: Recombinant human erythropoietin (rhEPO) has been shown to exert anti-apoptotic and anti-inflammatory effects after cerebral ischemia. Inflammatory cytokines interleukin-1β and -18 (IL-1β and IL-18) are crucial mediators of apoptosis and are maturated by multiprotein complexes… read more here.
Keywords: human microglial; post ischemic; migration phagocytosis; activation ... See more keywords
Comparative Analysis Identifies Similarities between the Human and Murine Microglial Sensomes
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DOI: 10.3390/ijms22031495
Abstract: One of the essential functions of microglia is to continuously sense changes in their environment and adapt to those changes. For this purpose, they use a set of genes termed the sensome. This sensome is… read more here.
Keywords: sensome; human microglial; analysis; microglial sensome ... See more keywords
Anti-Inflammatory Action of Dexmedetomidine on Human Microglial Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231710096
Abstract: Neuroinflammation, where inflammatory cytokines are produced in excess, contributes to the pathogenesis of delirium. Microglial cells play a central role in neuroinflammation by producing and releasing inflammatory cytokines in response to infection, tissue damage and… read more here.
Keywords: human microglial; inflammatory action; microglial cells; dex ... See more keywords