Reproducible generation of human midbrain organoids for in vitro modeling of Parkinson's disease.
Sign Up to like & getrecommendations! Published in 2020 at "Stem cell research"
DOI: 10.1016/j.scr.2020.101870
Abstract: The study of human midbrain development and midbrain related diseases, like Parkinson's disease (PD), is limited by deficiencies in the currently available and validated laboratory models. Three dimensional midbrain organoids represent an innovative strategy to… read more here.
Keywords: midbrain organoids; midbrain; human midbrain; parkinson disease ... See more keywords
Identity prediction errors in the human midbrain update reward-identity expectations in the orbitofrontal cortex
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DOI: 10.1038/s41467-018-04055-5
Abstract: There is general consensus that dopaminergic midbrain neurons signal reward prediction errors, computed as the difference between expected and received reward value. However, recent work in rodents shows that these neurons also respond to errors… read more here.
Keywords: reward identity; identity; human midbrain; prediction errors ... See more keywords
A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.52904
Abstract: Three-dimensional (3D) culture systems have fueled hopes to bring about the next generation of more physiologically relevant high-throughput screens (HTS). However, current protocols yield either complex but highly heterogeneous aggregates (‘organoids’) or 3D structures with… read more here.
Keywords: human midbrain; fully automated; midbrain organoids; high throughput ... See more keywords