Design and synthesis of novel benzyloxy-tethered-chromone-carboxamide derivatives as potent and selective human monoamine oxidase-b inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Papers"
DOI: 10.1007/s11696-020-01332-w
Abstract: A series of new bifunctional 7-benzyloxy-2, 3-dimethyl-4-oxo-4H-chromene-8-carboxamides 5a - 5 l were synthesized from 7-hydroxy 2,3 dimethyl chromone via key intermediate 7-benzyloxy 2,3 dimethyl-8-carboxylic acid using Jones oxidation and HBTU/HOBt (Hexafluorophosphate Benzotriazole Tetramethyl Uronium/Hydroxybenzotriazole) as selective… read more here.
Keywords: benzyloxy; human monoamine; chromone; monoamine oxidase ... See more keywords
Spectroelectrochemical study revealing the redox potential of human monoamine oxidase A
Sign Up to like & getrecommendations! Published in 2019 at "Electrochimica Acta"
DOI: 10.1016/j.electacta.2019.06.017
Abstract: Abstract Spectroelectrochemical measurements were performed on human monoamine oxidase A (MAO A) at pH 7.8, and the redox potential of the enzyme was determined. MAOs are membrane-bound flavoenzymes that catalyse the oxidation of different neurotransmitters… read more here.
Keywords: monoamine oxidase; spectroelectrochemical study; human monoamine; redox potential ... See more keywords
Potent and selective inhibition of human monoamine oxidase-B by 4-dimethylaminochalcone and selected chalcone derivatives.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.06.167
Abstract: Six synthetic (1-6) and six natural (7-12) chalcones were tested for human monoamine oxidases (hMAOs) and acetylcholinesterase (AChE) inhibitory activities. Compounds 4-dimethylaminochalcone (2), 4'-chloro-4-dimethylaminochalcone (5), and 2,4'-dichloro-4-dimethylaminochalcone (1) potently inhibited hMAO-B with IC50 values of… read more here.
Keywords: inhibited hmao; human monoamine; dimethylaminochalcone; ic50 ... See more keywords
Bromophenols from Symphyocladia latiuscula Target Human Monoamine Oxidase and Dopaminergic Receptors for the Management of Neurodegenerative Diseases.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.0c00007
Abstract: Progressive degeneration of dopaminergic neurons in the substantia nigra is the characteristic feature of Parkinson's disease (PD) and the severity accelerates with aging. Therefore, improving dopamine level or dopamine receptor signaling is a standard approach… read more here.
Keywords: human monoamine; monoamine oxidase; symphyocladia latiuscula;
Isoliquiritigenin, a potent human monoamine oxidase inhibitor, modulates dopamine D1, D3, and vasopressin V1A receptors
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-02843-6
Abstract: Isoliquiritigenin (= 4,2′,4′-Trihydroxychalcone) (ILG) is a major constituent of the Glycyrrhizae Rhizoma that has significant neuroprotective functions. In the present study, we re-examined the potential of ILG to inhibit human monoamine oxidase (hMAO) in vitro and… read more here.
Keywords: dopamine vasopressin; v1a receptors; vasopressin; human monoamine ... See more keywords
The conformational dynamics of wing gates Ile199 and Phe103 on the binding of dopamine and benzylamine substrates in human monoamine Oxidase B
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1734483
Abstract: The human Monoamine oxidase B (hMAO B) is an important flavoenzyme that metabolizes several biogenic amine neurotransmitters, regulates their concentration in the living cells and is involved in different neurological disorders and diseases. MD-simulation studies… read more here.
Keywords: ile199 phe103; human monoamine; conformational dynamics; monoamine oxidase ... See more keywords
Molecular Modeling and Experimental Evaluation of Non-Chiral Components of Bergamot Essential Oil with Inhibitory Activity against Human Monoamine Oxidases
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27082467
Abstract: Human monoamine oxidases (hMAOs) are well-established targets for the treatment of neurological disorders such as depression, Parkinson’s disease and Alzheimer’s disease. Despite the efforts carried out over the years, few selective and reversible MAO inhibitors… read more here.
Keywords: monoamine oxidases; essential oil; bergamot essential; human monoamine ... See more keywords
Inhibition of Human Monoamine Oxidases A and B by Specialized Metabolites Present in Fresh Common Fruits and Vegetables
Sign Up to like & getrecommendations! Published in 2022 at "Plants"
DOI: 10.3390/plants11030346
Abstract: Diets rich in fruits and vegetables are associated with better psychological wellbeing and cognitive functions, although it is unclear which molecules and mechanisms are involved. One potential explanation is the inhibition of monoamine oxidases (MAOs),… read more here.
Keywords: inhibition human; monoamine oxidases; human monoamine; fruits vegetables ... See more keywords