Homology modeling and site-directed mutagenesis identify amino acid residues underlying the substrate selection mechanism of human monocarboxylate transporters 1 (hMCT1) and 4 (hMCT4)
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DOI: 10.1007/s00018-019-03151-z
Abstract: Human monocarboxylate transporters (hMCTs/SLC16As) mediate the transport of monocarboxylic compounds across plasma membranes. Among the hMCTs, hMCT1 and hMCT4 are expressed in various tissues, and transport substrates involved in energy metabolism. Both transporters mediate l-lactate… read more here.
Keywords: human monocarboxylate; acid residues; amino acid; hmct1 hmct4 ... See more keywords