Epitope analysis of human monoclonal antibodies from a patient with autoimmune factor XIII deficiency reveals their inhibitory mechanisms
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14606
Abstract: Autoimmune coagulation factor XIII (FXIII) deficiency (AiF13D) is a bleeding disorder caused by anti‐FXIII autoantibodies. Recently, we generated human monoclonal antibodies (mAbs) from the peripheral blood of an AiF13D patient and classified them into three… read more here.
Keywords: factor xiii; monoclonal antibodies; human monoclonal; deficiency ... See more keywords
A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2017 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2017.10.015
Abstract: ABSTRACT Infections with hepatitis C virus (HCV) represent a worldwide health burden and a prophylactic vaccine is still not available. Liver transplantation (LT) is often the only option for patients with HCV‐induced end‐stage liver disease.… read more here.
Keywords: human monoclonal; mab 2a5; hcv; virus ... See more keywords
Generation and characterization of a potent fully human monoclonal antibody against the interleukin‐23 receptor
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.03.036
Abstract: ABSTRACT Interleukin (IL)‐12 and IL‐23 share a common subunit (p40) and function in T‐helper (Th) 1 and Th17 immunity, respectively. Anti‐IL‐12/23p40 and specific anti‐IL‐23 antibodies are currently in clinical use for psoriasis and undergoing trials… read more here.
Keywords: human monoclonal; antibody; fully human; generation characterization ... See more keywords
Characterization of human monoclonal antibodies that neutralize multiple poliovirus serotypes.
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2017.03.038
Abstract: Following the eradication of wild poliovirus (PV), achieving and maintaining a polio-free status will require eliminating potentially pathogenic PV strains derived from the oral attenuated vaccine. For this purpose, a combination of non-cross-resistant drugs, such… read more here.
Keywords: antibodies neutralize; monoclonal antibodies; human monoclonal; cross neutralization ... See more keywords
Crowd on a Chip: Label-Free Human Monoclonal Antibody Arrays for Serotyping Influenza.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.8b02479
Abstract: Rapid changes in influenza A virus (IAV) antigenicity create challenges in surveillance, disease diagnosis, and vaccine development. Further, serological methods for studying antigenic properties of influenza viruses often rely on animal models and therefore may… read more here.
Keywords: human monoclonal; influenza; antibody; label free ... See more keywords
A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04704-9
Abstract: The high rate of antigenic drift in seasonal influenza viruses necessitates frequent changes in vaccine composition. Recent seasonal H3 vaccines do not protect against swine-origin H3N2 variant (H3N2v) strains that recently have caused severe human… read more here.
Keywords: multifunctional human; human monoclonal; neutralizing antibody; conserved epitope ... See more keywords
A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21955-1
Abstract: Malaria elimination requires tools that interrupt parasite transmission. Here, we characterize B cell receptor responses among Malian adults vaccinated against the first domain of the cysteine-rich 230 kDa gamete surface protein Pfs230, a key protein in… read more here.
Keywords: transmission; human monoclonal; antibody blocks; blocks malaria ... See more keywords
647. Characterization and Development of Human Monoclonal Antibodies to Pneumococcal Serotype 3
Sign Up to like & getrecommendations! Published in 2018 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofy210.654
Abstract: Abstract Background Streptococcus pneumoniae is the main bacterial cause of pneumonia in the United States and globally. Although pneumococcal conjugate vaccines are highly effective against invasive pneumococcal disease, they are less effective against pneumonia, particularly… read more here.
Keywords: monoclonal antibodies; human monoclonal; vh3; serotype ... See more keywords
A human monoclonal antibody against the distal carboxyl terminus of ADAMTS‐13 modulates its susceptibility to an inhibitor in thrombotic thrombocytopenic purpura
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15332
Abstract: Immune thrombotic thrombocytopenic purpura (iTTP) is a potentially fatal thrombotic microangiopathy, resulting from a severe deficiency of plasma ADAMTS‐13 (A Disintegrin And Metalloproteinase with ThromboSpondin type 1 motif, member 13) activity. IgG‐type autoantibodies are primarily… read more here.
Keywords: human monoclonal; thrombotic thrombocytopenic; adamts; thrombocytopenic purpura ... See more keywords
Native Human Monoclonal Antibodies with Potent Cross-Lineage Neutralization of Influenza B Viruses
Sign Up to like & getrecommendations! Published in 2018 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02269-17
Abstract: ABSTRACT Although antibodies that effectively neutralize a broad set of influenza viruses exist in the human antibody repertoire, they are rare. We used a single-cell screening technology to identify rare monoclonal antibodies (MAbs) that recognized… read more here.
Keywords: stalk binding; influenza viruses; monoclonal antibodies; human monoclonal ... See more keywords
Identification and Characterization of Human Monoclonal Antibodies for Immunoprophylaxis against Enterotoxigenic Escherichia coli Infection
Sign Up to like & getrecommendations! Published in 2018 at "Infection and Immunity"
DOI: 10.1128/iai.00355-18
Abstract: Enterotoxigenic Escherichia coli (ETEC) causes diarrheal illness in infants in the developing world and travelers to countries where the disease is endemic, including military personnel. ETEC infection of the host involves colonization of the small… read more here.
Keywords: escherichia coli; human monoclonal; infection; colonization ... See more keywords