NLRP3 inflammasome triggers interleukin‐37 release from human monocytes
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149724
Abstract: IL‐37 is an anti‐inflammatory member of the IL‐1 family that dampens inflammation associated with many noncommunicable diseases. However, mechanisms of IL‐37 regulation remain understudied. We aimed to investigate the enzymatic cleavage of IL‐37 that potentiates… read more here.
Keywords: cleavage; inflammasome triggers; secretion; release ... See more keywords
Glibenclamide alters interleukin-8 and interleukin-1β of primary human monocytes from diabetes patients against Mycobacterium tuberculosis infection.
Sign Up to like & getrecommendations! Published in 2020 at "Tuberculosis"
DOI: 10.1016/j.tube.2020.101939
Abstract: Type 2 diabetes mellitus (T2DM) is an important risk factor for development of tuberculosis (TB). Our previous study showed glibenclamide, an anti-diabetic drug used to control blood glucose concentration, reduced interleukin (IL)-8 secretion from primary… read more here.
Keywords: monocytes diabetes; human monocytes; infection; tuberculosis ... See more keywords
Activation of human monocytes by colloidal aluminium salts.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2019.08.014
Abstract: Subunit vaccines often contain colloidal aluminium salt-based adjuvants to activate the innate immune system. These aluminium salts consist of micrometre-sized aggregates. It is well known that particle size affects the adjuvant effect of particulate adjuvants.… read more here.
Keywords: colloidal aluminium; aluminium; human monocytes; activation human ... See more keywords
Salmonella typhimurium-induced IL-1 release from primary human monocytes requires NLRP3 and can occur in the absence of pyroptosis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-07081-3
Abstract: Large molecular complexes known as inflammasomes regulate the release of IL-1β from immune cells in response to infection and injury. Salmonella typhimurium infection is reported to activate NLRP3 and NLRC4 inflammasomes which are subsequently involved… read more here.
Keywords: salmonella; pyroptosis; human monocytes; typhimurium ... See more keywords
Measuring volume kinetics of human monocytes in response to cryoprotectants using microfluidic technologies
Sign Up to like & getrecommendations! Published in 2019 at "Applied Physics Letters"
DOI: 10.1063/1.5096199
Abstract: Cryopreservation is a common strategy for the preservation of biological cells and tissues. While conventional platforms such as cell culture well plate systems enable measuring cell responses to various cryoprotectants, the drawbacks associated with capturing… read more here.
Keywords: response; human monocytes; microfluidic technologies; volume kinetics ... See more keywords
ROCK2 interacts with p22phox to phosphorylate p47phox and to control NADPH oxidase activation in human monocytes.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2209184120
Abstract: Monocytes play a key role in innate immunity by eliminating pathogens, releasing high levels of cytokines, and differentiating into several cell types, including macrophages and dendritic cells. Similar to other phagocytes, monocytes produce superoxide anions… read more here.
Keywords: oxidase activation; human monocytes; nadph oxidase; rock2 interacts ... See more keywords
MO451GUANIDINYLATED APOLIPOPROTEIN C3 (APOC3) A NOVEL PLAYER IN CKD AND CKD-ASSOCIATED CARDIOVASCULAR DISEASES
Sign Up to like & getrecommendations! Published in 2021 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfab090.0013
Abstract: Cardiovascular diseases (CVD) and chronic kidney diseases (CKD) are highly prevalent in Western populations and account for a substantial proportion of mortality. We found that apolipoprotein C-3 (ApoC3), a constituent of triglyceride-rich lipoproteins, induces alternative… read more here.
Keywords: cardiovascular diseases; apolipoprotein apoc3; ckd; apoc3 novel ... See more keywords
Minor compounds from virgin olive oil attenuate LPS-induced inflammation via visfatin-related gene modulation on primary human monocytes.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of food biochemistry"
DOI: 10.1111/jfbc.12941
Abstract: We have analyzed the effects of minor compounds found in the unsaponifiable fraction (UF) and in the phenolic fraction (PF) of virgin olive oil (VOO) on LPS-induced inflammatory response via visfatin modulation in human monocytes.… read more here.
Keywords: via visfatin; human monocytes; modulation; minor compounds ... See more keywords
Activation of the TREM‐1 pathway in human monocytes by periodontal pathogens and oral commensal bacteria
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Oral Microbiology"
DOI: 10.1111/omi.12169
Abstract: Periodontitis is a highly prevalent disease caused in part by an aberrant host response to the oral multi-species biofilm. A balance between the oral bacteria and host immunity is essential for oral health. Imbalances in… read more here.
Keywords: human monocytes; trem pathway; trem; pathway human ... See more keywords
Candida albicans Induces Cross-Kingdom miRNA Trafficking in Human Monocytes To Promote Fungal Growth
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.03563-21
Abstract: Over the last decade, communication between immune cells by extracellular vesicle-associated miRNAs has emerged as an important regulator of the coordinated immune response. Therefore, a thorough understanding of the conversation occurring via miRNAs, especially during… read more here.
Keywords: fungal growth; growth; hsa mir; response ... See more keywords
P108/O28 Fatty acid oxidation can drive human monocyte derived CCL20 in the RA synovial environment
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-ewrr2019.96
Abstract: Career situation of first and presenting author Post-doctoral fellow. Introduction Metabolic pathways are considered to have a governing role in inflammatory cascades in myeloid cells. This is particularly evident in murine macrophages where glycolysis and… read more here.
Keywords: p108 o28; acid oxidation; fatty acid; environment ... See more keywords