RNA Editing in Human and Mouse Tissues.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0787-9_10
Abstract: Adenosine-to-inosine (A-to-I) RNA editing is a fundamental posttranscriptional mechanism that greatly diversifies the transcriptome in many living organisms, including mammals. Multiple studies have demonstrated the importance of this process not just in normal development and… read more here.
Keywords: mouse tissues; human mouse; rna editing; editing human ... See more keywords
Establishment of Human- and Mouse-Derived Gastric Primary Epithelial Cell Monolayers from Organoids.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8600-2_15
Abstract: Organoid cultures generated from gastrointestinal tissues have been an invaluable advancement for in vitro studies of physiological function and disease. Here we present a comprehensive protocol for the establishment and culture of human- and mouse-derived… read more here.
Keywords: cell monolayers; human mouse; epithelial cell; mouse derived ... See more keywords
C3aR and C5aR1 act as key regulators of human and mouse β-cell function
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2655-1
Abstract: AimsComplement components 3 and 5 (C3 and C5) play essential roles in the complement system, generating C3a and C5a peptides that are best known as chemotactic and inflammatory factors. In this study we characterised islet… read more here.
Keywords: function; human mouse; c3ar c5ar1;
Localization of aquaglyceroporins in human and murine white adipose tissue.
Sign Up to like & getrecommendations! Published in 2022 at "Histochemistry and cell biology"
DOI: 10.1007/s00418-022-02090-4
Abstract: The glycerol channel AQP7 facilitates glycerol efflux from adipose tissue (AT), and AQP7 deficiency has been suggested to promote obesity. However, the release of glycerol from AT is not fully blocked in AQP7-deficient mice, which… read more here.
Keywords: localization; aqp3 aqp9; glycerol; adipose tissue ... See more keywords
Maternally contributed Nlrp9b expressed in human and mouse ovarian follicles contributes to early murine preimplantation development
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Assisted Reproduction and Genetics"
DOI: 10.1007/s10815-020-01767-w
Abstract: The aim of the study is to investigate presence and role of the gene encoding the maternally contributed nucleotide-binding oligomerization domain (NOD)–like receptors with a pyrin domain (PYD)–containing protein 9 (NLRP9) in human and mouse… read more here.
Keywords: expressed human; human mouse; preimplantation; maternally contributed ... See more keywords
Integrative transcriptomic analysis of developing hematopoietic stem cells in human and mouse at single-cell resolution.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.04.058
Abstract: Current understanding of hematopoietic stem cell (HSC) development comes from mouse models is considered to be evolutionarily conserved in human. However, the cross-species comparison of the transcriptomic profiles of developmental HSCs at single-cell level is… read more here.
Keywords: human mouse; cell; hsc development; hematopoietic stem ... See more keywords
Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.09.002
Abstract: SUMMARY The effects of transgenically encoded human and mouse IL-18 on T cell proliferation and its application in boosting chimeric antigen receptor (CAR) T cells are presented. Robust enhancement of proliferation of IL-18-secreting human T… read more here.
Keywords: antitumor immunity; human mouse; proliferation; car cells ... See more keywords
refTSS: A Reference Data Set for Human and Mouse Transcription Start Sites.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.04.045
Abstract: Transcription starts at genomic positions called transcription start sites (TSSs), producing RNAs, and is mainly regulated by genomic elements and transcription factors binding around these TSSs. This indicates that TSSs may be a better unit… read more here.
Keywords: transcription; human mouse; reference; start sites ... See more keywords
An integrated expression atlas of miRNAs and their promoters in human and mouse
Sign Up to like & getrecommendations! Published in 2017 at "Nature Biotechnology"
DOI: 10.1038/nbt.3947
Abstract: MicroRNAs (miRNAs) are short non-coding RNAs with key roles in cellular regulation. As part of the fifth edition of the Functional Annotation of Mammalian Genome (FANTOM5) project, we created an integrated expression atlas of miRNAs… read more here.
Keywords: mirnas promoters; atlas mirnas; integrated expression; human mouse ... See more keywords
Comparative transcriptomics in human and mouse
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Genetics"
DOI: 10.1038/nrg.2017.19
Abstract: Cross-species comparisons of genomes, transcriptomes and gene regulation are now feasible at unprecedented resolution and throughput, enabling the comparison of human and mouse biology at the molecular level. Insights have been gained into the degree… read more here.
Keywords: comparative transcriptomics; human mouse; physiology; biology ... See more keywords
A non-conserved amino acid variant regulates differential signalling between human and mouse CD28
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03385-8
Abstract: CD28 superagonistic antibodies (CD28SAb) can preferentially activate and expand immunosuppressive regulatory T cells (Treg) in mice. However, pre-clinical trials assessing CD28SAbs for the therapy of autoimmune diseases reveal severe systemic inflammatory response syndrome in humans,… read more here.
Keywords: amino acid; human mouse; mouse cd28; cd28 ... See more keywords