Biophysical and Structural Methods to Study the bHLHZip Region of Human c-MYC.
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DOI: 10.1007/978-1-0716-1476-1_3
Abstract: The C-terminal region of the c-MYC transcription factor consists of approximately 100 amino acids that in its native state does not adopt a stable structure. When this region binds to the obligatory partner MAX via… read more here.
Keywords: methods study; biophysical structural; structural methods; human myc ... See more keywords
Transactivation Domain of Human c-Myc Is Essential to Alleviate Poly(Q)-Mediated Neurotoxicity in Drosophila Disease Models
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DOI: 10.1007/s12031-017-0910-4
Abstract: Polyglutamine (poly(Q)) disorders, such as Huntington’s disease (HD) and spinocerebellar ataxias, represent a group of neurological disorders which arise due to an atypically expanded poly(Q) tract in the coding region of the affected gene. Pathogenesis… read more here.
Keywords: poly; poly mediated; transactivation domain; mediated neurotoxicity ... See more keywords
Structural insight for the recognition of G-quadruplex structure at human c-myc promoter sequence by flavonoid Quercetin
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DOI: 10.1038/s41598-017-03906-3
Abstract: Small molecule ligands that could stabilize G-quadruplex structure formed at the promoter region of human c-myc oncogene will regulate its expression in cancer cells. Flavonoids, a group of naturally available small molecule, have been known… read more here.
Keywords: quadruplex structure; myc promoter; structure; human myc ... See more keywords