In vitro induction of quiescence in isolated primary human myoblasts
Sign Up to like & getrecommendations! Published in 2020 at "Cytotechnology"
DOI: 10.1007/s10616-019-00365-8
Abstract: Adult skeletal muscle stem cells, satellite cells, remain in an inactive or quiescent state in vivo under physiological conditions. Progression through the cell cycle, including activation of quiescent cells, is a tightly regulated process. Studies… read more here.
Keywords: human myoblasts; quiescence; induction quiescence; vitro induction ... See more keywords
Constricted Migration of Human Myoblasts Impairs Motility, Nuclear Integrity and Differentiation
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733022
Abstract: Introduction: Upon injury, muscle stem cells (MuSCs) undergo activation, proliferation, migration, differentiation and fusion to regenerate muscle. MuSCs sense and respond to the mechanical microenvironment of the tissue while migrating through the interstitial matrix to… read more here.
Keywords: constricted migration; human myoblasts; physiology; migration ... See more keywords
Impact of vitamin D and vitamin D receptor TaqI polymorphism in primary human myoblasts
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DOI: 10.1530/ec-19-0194
Abstract: The CC genotype of the vitamin D receptor (VDR) polymorphism TaqI rs731236 has previously been associated with a higher risk of developing myopathy compared to TT carriers. However, the mechanistic role of this polymorphism in… read more here.
Keywords: differentiation; human myoblasts; polymorphism; primary human ... See more keywords
Blockade of Store-Operated Calcium Entry Reduces IL-17/TNF Cytokine-Induced Inflammatory Response in Human Myoblasts
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.03170
Abstract: Muscle inflammation as in idiopathic inflammatory myopathies (IIM) leads to muscle weakness, mononuclear cell infiltration, and myofiber dysfunction affecting calcium channels. The effects of interleukin-17A (IL-17) and tumor necrosis factor-α (TNFα) on inflammation and calcium… read more here.
Keywords: human myoblasts; store operated; tnf; muscle ... See more keywords
CTG-Repeat Detection in Primary Human Myoblasts of Myotonic Dystrophy Type 1
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.686735
Abstract: Myotonic dystrophy type 1 (DM1) is an autosomal dominant multisystemic disorder caused by unstable CTG-repeat expansions in the DMPK gene. Tissue mosaicism has been described for the length of these repeat expansions. The most obvious… read more here.
Keywords: human myoblasts; ctg repeat; dystrophy type; repeat ... See more keywords
Gain-of-Function Dynamin-2 Mutations Linked to Centronuclear Myopathy Impair Ca2+-Induced Exocytosis in Human Myoblasts
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231810363
Abstract: Gain-of-function mutations of dynamin-2, a mechano-GTPase that remodels membrane and actin filaments, cause centronuclear myopathy (CNM), a congenital disease that mainly affects skeletal muscle tissue. Among these mutations, the variants p.A618T and p.S619L lead to… read more here.
Keywords: centronuclear myopathy; gain function; exocytosis; human myoblasts ... See more keywords
Neuronal Agrin Promotes Proliferation of Primary Human Myoblasts in an Age-Dependent Manner
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911784
Abstract: Neuronal agrin, a heparan sulphate proteoglycan secreted by the α-motor neurons, promotes the formation and maintenance of the neuromuscular junction by binding to Lrp4 and activating muscle-specific kinase (MuSK). Neuronal agrin also promotes myogenesis by… read more here.
Keywords: age dependent; human myoblasts; proliferation; neuronal agrin ... See more keywords