Effects of Phthalate Esters on Human Myometrial and Fibroid Cells: Cell Culture and NOD-SCID Mouse Data
Sign Up to like & getrecommendations! Published in 2020 at "Reproductive Sciences"
DOI: 10.1007/s43032-020-00341-0
Abstract: Evidence is growing that phthalate esters play an important role in the pathogenesis of estrogen-dependent gynecologic diseases, especially uterine fibroids. We aimed to investigate whether in vitro treatment with di-(2-ethylhexyl)-phthalate (DEHP) affects angiogenesis, proliferation, and… read more here.
Keywords: phthalate esters; myometrial fibroid; expression; fibroid ... See more keywords
Phosphorylation of proteins during human myometrial contractions: A phosphoproteomic approach.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2016.12.047
Abstract: Phasic myometrial contractility is a key component of human parturition and the contractions are driven by reversible phosphorylation of myosin light chains catalyzed by the calcium (Ca2+)-dependent enzyme myosin light chain kinase (MYLK). Other yet… read more here.
Keywords: phosphorylation proteins; myometrial contractions; approach; human myometrial ... See more keywords
Cooperative effects of sequential PGF2α and IL-1β on IL-6 and COX-2 expression in human myometrial cells†.
Sign Up to like & getrecommendations! Published in 2019 at "Biology of reproduction"
DOI: 10.1093/biolre/ioz029
Abstract: The change from the state of pregnancy to the state of parturition, which we call uterine transitioning, requires the actions of inflammatory mediators and results in an activated uterus capable of performing the physiology of… read more here.
Keywords: pgf2; cox; expression; cooperative effects ... See more keywords
Human myometrial artery function and endothelial cell calcium signalling are reduced by obesity: Can this contribute to poor labour outcomes?
Sign Up to like & getrecommendations! Published in 2019 at "Acta Physiologica"
DOI: 10.1111/apha.13341
Abstract: Determining how obesity affects function in human myometrial arteries, to help understand why childbirth has poor outcomes in obese women. read more here.
Keywords: obesity; function endothelial; endothelial cell; artery function ... See more keywords
Sphingosine 1-Phosphate Activates S1PR3 to Induce a Proinflammatory Phenotype in Human Myometrial Cells
Sign Up to like & getrecommendations! Published in 2023 at "Endocrinology"
DOI: 10.1210/endocr/bqad066
Abstract: Abstract One of the common mechanisms responsible for obstetric complications, affecting millions of women every year, is abnormal uterine contractility. Despite the critical importance of this process for women's health, the mechanisms of uterine contraction… read more here.
Keywords: proinflammatory phenotype; s1p; myometrial cells; human myometrial ... See more keywords