H3K27ac Is Essential for Human Naive Pluripotency Modulated by m6A‐Driven EP300 Expression
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202507549
Abstract: Human pluripotent stem cells (hPSCs) can transition between primed and naive states, each defined by unique epigenetic features crucial for early human development. However, the precise regulatory mechanisms of these transitions, particularly involving the roles… read more here.
Keywords: human naive; ep300 expression; naive pluripotency; h3k27ac ... See more keywords
Investigate Global Chromosomal Interaction by Hi-C in Human Naive CD4 T Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7514-3_15
Abstract: Hi-C is a methodology developed to reveal chromosomal interactions from a genome-wide perspective. Here, we described a protocol for generating Hi-C sequencing libraries in resting and activated human naive CD4 T cells to investigate activation-induced… read more here.
Keywords: human naive; cd4 cells; cells investigate; investigate global ... See more keywords
Identification of ALPPL2 as a Naive Pluripotent State-Specific Surface Protein Essential for Human Naive Pluripotency Regulation.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.02.090
Abstract: Human naive pluripotent stem cells established from the epiblasts of preimplantation blastocysts provide a useful model for mechanistic studies of pluripotency regulation and lineage differentiation. Important advances have been made to optimize culture conditions and… read more here.
Keywords: human naive; pluripotency regulation; pluripotency; specific surface ... See more keywords
The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen
Sign Up to like & getrecommendations! Published in 2018 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aat0381
Abstract: Inspection of the naive B cell repertoire specific for an HIV vaccine immunogen provides actionable information for human vaccine design and advancement. Learning from naive B cells Despite decades of intensive research, HIV vaccines are… read more here.
Keywords: cell repertoire; human naive; naive cell; vaccine ... See more keywords