Experimental Acute Exposure to Thirdhand Smoke and Changes in the Human Nasal Epithelial Transcriptome
Sign Up to like & getrecommendations! Published in 2019 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2019.6362
Abstract: Key Points Question Does acute inhalation of thirdhand smoke alter the transcriptome of the human nasal epithelium? Findings This randomized clinical trial exposed 4 healthy, nonsmoking women to clean air, which altered the expression of… read more here.
Keywords: human nasal; exposure thirdhand; thirdhand smoke; acute exposure ... See more keywords
Differential susceptibility to SARS‐CoV‐2 in the normal nasal mucosa and in chronic sinusitis
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202249805
Abstract: Human nasal mucosa is susceptible to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and serves as a reservoir for viral replication before spreading to other organs (e.g. the lung and brain) and transmission to… read more here.
Keywords: nasal mucosa; cov infection; human nasal; sars cov ... See more keywords
Novel involvement of PLD–PKCδ–CREB axis in regulating FGF‐2‐mediated pentraxin 3 production in human nasal fibroblast cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30657
Abstract: A higher expression level of mitogenic fibroblast growth factor‐2 (FGF‐2) has been reported in human nasal mucus of both chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). Meanwhile, we have… read more here.
Keywords: creb; pkc creb; fgf; human nasal ... See more keywords
Evaluation of Collagen Gel-Associated Human Nasal Septum-Derived Chondrocytes As a Clinically Applicable Injectable Therapeutic Agent for Cartilage Repair
Sign Up to like & getrecommendations! Published in 2020 at "Tissue Engineering and Regenerative Medicine"
DOI: 10.1007/s13770-020-00261-9
Abstract: Background: Articular cartilage injury has a poor repair ability and limited regeneration capacity with therapy based on articular chondrocytes (ACs) implantation. Here, we validated the hypothesis that human nasal septum-derived chondrocytes (hNCs) are potent therapeutic… read more here.
Keywords: collagen; medicine; human nasal; hnc collagen ... See more keywords
Investigation of the impact of PM2.5 on the ciliary motion of human nasal epithelial cells.
Sign Up to like & getrecommendations! Published in 2019 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2019.05.274
Abstract: Nasal epithelium provides a physical barrier to potentially harmful stimuli. Cilia, which is on the apical side of the human nasal epithelial cells (HNEpCs), plays a critical role in removing inhaled harmful matter. Ciliary beat… read more here.
Keywords: pm2; human nasal; impact; exposure ... See more keywords
Comparison of micron- and nano-particle transport in the human nasal cavity with a focus on the olfactory region
Sign Up to like & getrecommendations! Published in 2021 at "Computers in biology and medicine"
DOI: 10.1016/j.compbiomed.2020.104103
Abstract: Intranasal administration of drugs serves as a promising, noninvasive option for the treatment of various disorders of the central nervous system and upper respiratory tract. Predictive, ie, realistic and accurate, particle tracking in the human… read more here.
Keywords: human nasal; deposition; particle; olfactory region ... See more keywords
Interleukin‐33 induces mucin gene expression and goblet cell hyperplasia in human nasal epithelial cells
Sign Up to like & getrecommendations! Published in 2017 at "Cytokine"
DOI: 10.1016/j.cyto.2016.10.010
Abstract: HighlightsIL‐33 was upregulated in nasal polyps of eosinophilic chronic rhinosinusitis.IL‐33 increase MUC5AC gene and MUC5AC protein in primary human nasal epithelial cell.IL‐33 induces goblet cell hyperplasia in primary human nasal epithelial cell. Abstract We investigated… read more here.
Keywords: nasal epithelial; human nasal; cell hyperplasia; goblet cell ... See more keywords
Subject-variability effects on micron particle deposition in human nasal cavities
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Aerosol Science"
DOI: 10.1016/j.jaerosci.2017.10.008
Abstract: Abstract Validated computer simulations of the airflow and particle dynamics in human nasal cavities are important for local, segmental and total deposition predictions of both inhaled toxic and therapeutic particles. Considering three, quite different subject-specific… read more here.
Keywords: human nasal; deposition; nasal cavities; particle ... See more keywords
Preclinical assessment of transplantable human nasal mucosal epithelial cell sheets
Sign Up to like & getrecommendations! Published in 2021 at "Regenerative Therapy"
DOI: 10.1016/j.reth.2021.03.006
Abstract: Introduction We previously reported a new cell transplantation therapy for patients with intractable otitis media using autologous nasal mucosal epithelial cell sheets, manufactured using temperature-responsive cell culture inserts. The current study aimed to verify whether… read more here.
Keywords: cell sheets; nasal mucosal; human nasal; mucosal epithelial ... See more keywords
MicroRNA‐146a induction during influenza H3N2 virus infection targets and regulates TRAF6 levels in human nasal epithelial cells (hNECs)
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2017.01.011
Abstract: ABSTRACT We have previously shown that human nasal epithelial cells (hNECs) are highly permissive cells for respiratory viruses including influenza A virus (IAV) and respiratory syncytial virus. Recent studies have indicated that microRNAs (miRNAs) are… read more here.
Keywords: h3n2; human nasal; infection; influenza ... See more keywords
FcγRIII stimulation breaks the tolerance of human nasal epithelial cells to bacteria through cross-talk with TLR4
Sign Up to like & getrecommendations! Published in 2019 at "Mucosal Immunology"
DOI: 10.1038/s41385-018-0129-x
Abstract: The nasal cavity displays immune tolerance to commensal bacteria under homeostatic conditions, which is rapidly converted to a pro-inflammatory response upon infection. Yet, the factors that control this conversion are still largely unknown. Here, we… read more here.
Keywords: epithelial cells; tolerance; human nasal; riii stimulation ... See more keywords