Spontaneous Differentiation of Human Neural Stem Cells on Nanodiamonds
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Biosystems"
DOI: 10.1002/adbi.201800299
Abstract: The potential use of stem cells in regenerative medicine requires the ability to be able to control stem cell fate as cellular networks are developed. Here, nanodiamonds (≈10 nm) are supported on glass and shown… read more here.
Keywords: spontaneous differentiation; human neural; stem; stem cells ... See more keywords
An adherent‐cell depletion technique to generate human neural progenitors and neurons
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28591
Abstract: Existing methodologies to produce human neural stem cells and neurons from embryonic stem cells frequently involve multistep processes and the use of complex and expensive media components, cytokines or small molecules. Here, we report a… read more here.
Keywords: technique; technique generate; progenitors neurons; human neural ... See more keywords
Toward the next generation of vascularized human neural organoids
Sign Up to like & getrecommendations! Published in 2022 at "Medicinal Research Reviews"
DOI: 10.1002/med.21922
Abstract: Thanks to progress in the development of three‐dimensional (3D) culture technologies, human central nervous system (CNS) development and diseases have been gradually deciphered by using organoids derived from human embryonic stem cells (hESCs) or human… read more here.
Keywords: neural organoids; toward next; vascularized human; next generation ... See more keywords
Genetic mutations in ribosomal biogenesis gene TCOF1 identified in human neural tube defects
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.2150
Abstract: Rare mutations in multiple genes have been associated with human neural tube defects (NTDs), but their causative roles in NTDs disease are poorly understood. Insufficiency of the ribosomal biogenesis gene treacle ribosome biogenesis factor 1(Tcof1)… read more here.
Keywords: human neural; biogenesis; tube defects; tcof1 ... See more keywords
Substrate stiffness modulates the multipotency of human neural crest derived ectomesenchymal stem cells via CD44 mediated PDGFR signaling.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.03.022
Abstract: Mesenchymal stem cells (MSCs) have been isolated from various mesodermal and ectodermal tissues. While the phenotypic and functional heterogeneity of MSCs stemming from their developmental origins has been acknowledged, the genetic and environmental factors underpinning… read more here.
Keywords: human neural; substrate stiffness; neural crest; stem ... See more keywords
Nanogold Neuroprotection in Human Neural Stem Cells Against Amyloid-beta-induced Mitochondrial Dysfunction
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2020.03.040
Abstract: Alzheimer's disease (AD) is a neuronal dementia with progressive memory loss. Amyloid-beta (Aβ) peptides has major effect in the neurodegenerative disorder, which are thought to promote mitochondrial dysfunction in AD brains. Anti-AD drugs acting upon… read more here.
Keywords: amyloid beta; dysfunction; aunps; human neural ... See more keywords
Dysregulation of the glutamatergic receptors after antidepressant treatment in human neural progenitor cells
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Psychiatry"
DOI: 10.1038/mp.2016.138
Abstract: Dysregulation of the glutamatergic receptors after antidepressant treatment in human neural progenitor cells read more here.
Keywords: human neural; treatment human; dysregulation glutamatergic; antidepressant treatment ... See more keywords
Convergent and distributed effects of the 3q29 deletion on the human neural transcriptome
Sign Up to like & getrecommendations! Published in 2021 at "Translational Psychiatry"
DOI: 10.1038/s41398-021-01435-2
Abstract: The 3q29 deletion (3q29Del) confers high risk for schizophrenia and other neurodevelopmental and psychiatric disorders. However, no single gene in this interval is definitively associated with disease, prompting the hypothesis that neuropsychiatric sequelae emerge upon… read more here.
Keywords: 3q29 genes; 3q29 deletion; human neural; convergent distributed ... See more keywords
Human neural tube morphogenesis in vitro by geometric constraints.
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-021-04026-9
Abstract: Understanding human organ formation is a scientific challenge with far-reaching medical implications1,2. Three-dimensional stem-cell cultures have provided insights into human cell differentiation3,4. However, current approaches use scaffold-free stem-cell aggregates, which develop non-reproducible tissue shapes and… read more here.
Keywords: tube; neural ectoderm; human neural; neural tube ... See more keywords
Modelling human CNS injury with human neural stem cells in 2- and 3-Dimensional cultures
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-62906-y
Abstract: The adult human central nervous system (CNS) has very limited regenerative capability, and injury at the cellular and molecular level cannot be studied in vivo . Modelling neural damage in human systems is crucial to… read more here.
Keywords: human cns; dimensional cultures; human neural; damage ... See more keywords
Inducible Alpha-Synuclein Expression Affects Human Neural Stem Cells' Behavior.
Sign Up to like & getrecommendations! Published in 2018 at "Stem cells and development"
DOI: 10.1089/scd.2018.0011
Abstract: Converging evidence suggest that levels of alpha-synuclein (aSyn) expression play a critical role in Parkinson's disease (PD). Several mutations of the SNCA gene, encoding for aSyn have been associated to either the familial or the… read more here.
Keywords: stem cells; asyn; human neural; expression ... See more keywords