Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlaa007
Abstract: Human neurodegenerative diseases can be characterized as disorders of protein aggregation. As a key player in cellular autophagy and the ubiquitin proteasome system, p62 may represent an effective immunohistochemical target, as well as mechanistic operator,… read more here.
Keywords: 5g3 2a5; monoclonal antibodies; novel monoclonal; neurodegenerative diseases ... See more keywords
Role of microRNA (miRNA) and Viroids in Lethal Diseases of Plants and Animals. Potential Contribution to Human Neurodegenerative Disorders
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry (Moscow)"
DOI: 10.1134/s0006297918090031
Abstract: Both plants and animals have adopted a common strategy of using ~18–25-nucleotide small non-coding RNAs (sncRNAs), known as microRNAs (miRNAs), to transmit DNA-based epigenetic information. miRNAs (i) shape the total transcriptional output of individual cells;… read more here.
Keywords: microrna mirna; role microrna; mirna viroids; plants animals ... See more keywords
STING-Triggered CNS Inflammation in Human Neurodegenerative Diseases
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11051375
Abstract: Background: Some neurodegenerative diseases have an element of neuroinflammation that is triggered by viral nucleic acids, resulting in the generation of type I interferons. In the cGAS-STING pathway, microbial and host-derived DNA bind and activate… read more here.
Keywords: sting pathway; human neurodegenerative; cgas sting; neurodegenerative diseases ... See more keywords
The Role of Extracellular Matrix in Human Neurodegenerative Diseases
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911085
Abstract: The dense neuropil of the central nervous system leaves only limited space for extracellular substances free. The advent of immunohistochemistry, soon followed by advanced diagnostic tools, enabled us to explore the biochemical heterogeneity and compartmentalization… read more here.
Keywords: role extracellular; matrix; extracellular matrix; disease ... See more keywords