In Vitro Effects of Chronic Spirolide Treatment on Human Neuronal Stem Cell Differentiation and Cholinergic System Development.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.8b00036
Abstract: Spirolides (SPX) are marine toxins, produced by dinoflagellates that act as potent antagonists of nicotinic acetylcholine receptors. These compounds are not toxic for humans, and since there are no reports of human intoxications caused by… read more here.
Keywords: neuronal stem; treatment; human neuronal; vitro ... See more keywords
Modelling human neuronal catecholaminergic pigmentation in rodents recapitulates age-related neurodegenerative deficits
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DOI: 10.1038/s41467-024-53168-7
Abstract: One key limitation in developing effective treatments for neurodegenerative diseases is the lack of models accurately mimicking the complex physiopathology of the human disease. Humans accumulate with age the pigment neuromelanin inside neurons that synthesize… read more here.
Keywords: age; brain; pigmentation; modelling human ... See more keywords
Susceptibility and cytokine responses of human neuronal cells to multiple circulating EV-A71 genotypes in India
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-97166-x
Abstract: Enterovirus-A71 (EV-A71) associated Hand, foot and mouth disease (HFMD) is a highly contagious viral infection affecting children in Asia–Pacific region and has become a major threat to public health. Although several EV-A71 genotypes (C, D,… read more here.
Keywords: susceptibility cytokine; neuronal cells; human neuronal; cytokine responses ... See more keywords
Neuroprotective effect of hypoxic preconditioning and neuronal activation in a in vitro human model of the ischemic penumbra
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neural Engineering"
DOI: 10.1088/1741-2552/abe68a
Abstract: Objective. In ischemic stroke, treatments to protect neurons from irreversible damage are urgently needed. Studies in animal models have shown that neuroprotective treatments targeting neuronal silencing improve brain recovery, but in clinical trials none of… read more here.
Keywords: ischemic penumbra; hypoxic preconditioning; model ischemic; human neuronal ... See more keywords
Induction of Chaperone Synthesis in Human Neuronal Cells Blocks Oxidative Stress-Induced Aging
Sign Up to like & getrecommendations! Published in 2025 at "Acta Naturae"
DOI: 10.32607/actanaturae.27531
Abstract: Oxidative stress accompanies many pathologies that are characterized by neuronal degradation leading to a deterioration of the disease. The main causes are the disruption of protein homeostasis and activation of irreversible processes of cell cycle… read more here.
Keywords: stress; oxidative stress; human neuronal; neuronal cells ... See more keywords
Transcriptome Dynamics of Human Neuronal Differentiation From iPSC
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.727747
Abstract: The generation and use of induced pluripotent stem cells (iPSCs) in order to obtain all differentiated adult cell morphologies without requiring embryonic stem cells is one of the most important discoveries in molecular biology. Among… read more here.
Keywords: differentiation; neuronal differentiation; transcriptome dynamics; human neuronal ... See more keywords
Cycle-Inhibiting Factor Is Associated with Burkholderia pseudomallei Invasion in Human Neuronal Cells
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11101439
Abstract: Simple Summary Neurological melioidosis, caused by Burkholderia pseudomallei, can lead to the development of severe symptoms associated with the nervous system. However, the pathogenic mechanism through which this bacterium infects neuronal cells has not been… read more here.
Keywords: cif; burkholderia pseudomallei; factor; human neuronal ... See more keywords
Transcriptome Profiling of Phenylalanine-Treated Human Neuronal Model: Spotlight on Neurite Impairment and Synaptic Connectivity
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms251810019
Abstract: Phenylketonuria (PKU) is the most common inherited disorder of amino acid metabolism, characterized by high levels of phenylalanine (Phe) in the blood and brain, leading to cognitive impairment without treatment. Nevertheless, Phe-mediated brain dysfunction is… read more here.
Keywords: neuronal model; neurite impairment; human neuronal; phe ... See more keywords