Rational optimization of a human neutralizing antibody of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2021 at "Computers in Biology and Medicine"
DOI: 10.1016/j.compbiomed.2021.104550
Abstract: SARS-CoV-2 has caused a worldwide epidemic of coronavirus disease 19 (COVID-19). Antibody drugs present an effective weapon for tens of millions of COVID-19 patients. Antibodies disrupting the interactions between the receptor-binding domain (RBD) of SARS-CoV-2… read more here.
Keywords: antibody; optimization human; human neutralizing; rational optimization ... See more keywords
A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-18159-4
Abstract: The novel highly transmissible human coronavirus SARS-CoV-2 is the causative agent of the COVID-19 pandemic. Thus far, there is no approved therapeutic drug specifically targeting this emerging virus. Here we report the isolation and characterization… read more here.
Keywords: panel human; targeting sars; human neutralizing; neutralizing mabs ... See more keywords
A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-2381-y
Abstract: An outbreak of coronavirus disease 2019 (COVID-19) 1 – 3 , caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 4 , has spread globally. Countermeasures are needed to treat and prevent further dissemination of the virus.… read more here.
Keywords: antibody targets; neutralizing antibody; cb6; human neutralizing ... See more keywords
SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies
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DOI: 10.1038/s41586-020-2852-1
Abstract: The coronavirus disease 2019 (COVID-19) pandemic presents an urgent health crisis. Human neutralizing antibodies that target the host ACE2 receptor-binding domain (RBD) of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike protein 1 – 5… read more here.
Keywords: rbds; antibody; human neutralizing; cov spike ... See more keywords
A fully human neutralizing monoclonal antibody targeting a highly conserved epitope of the human cytomegalovirus glycoprotein B
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DOI: 10.1371/journal.pone.0285672
Abstract: Human cytomegalovirus causes severe diseases in children (by congenital infection) and immunocompromised patients. Treatment with antiviral agents, such as ganciclovir, is limited by their toxicity. In this study, we investigated the effectiveness of a fully… read more here.
Keywords: fully human; glycoprotein; cytomegalovirus; human cytomegalovirus ... See more keywords