New 3‐unsubstituted isoxazolones as potent human neutrophil elastase inhibitors: Synthesis and molecular dynamic simulation
Sign Up to like & getrecommendations! Published in 2019 at "Drug Development Research"
DOI: 10.1002/ddr.21625
Abstract: Human neutrophil elastase (HNE) is a proteolytic enzyme belonging to the serine protease family and is involved in a variety of pathologies. Thus, compounds able to inhibit HNE represent promising therapeutics for the treatment of… read more here.
Keywords: unsubstituted isoxazolones; human neutrophil; neutrophil elastase; new unsubstituted ... See more keywords
L‐selectin expression is regulated by CXCL8‐induced reactive oxygen species produced during human neutrophil rolling
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201847710
Abstract: Neutrophils destroy invading microorganisms by phagocytosis by bringing them into contact with bactericidal substances, among which ROS are the most important. However, ROS also function as important physiological regulators of cellular signaling pathways. Here, we… read more here.
Keywords: oxygen; response; cxcl8; human neutrophil ... See more keywords
Sequence preference and scaffolding requirement for the inhibition of human neutrophil elastase by ecotin peptide
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4274
Abstract: Human neutrophil elastase (hNE) is an abundant serine protease that is a major constituent of lung elastolytic activity. However, when secreted in excess, if not properly attenuated by selective inhibitor proteins, it can have detrimental… read more here.
Keywords: ecotin; inhibition; sequence; neutrophil elastase ... See more keywords
Synthesis and evaluation of benzenesulfonic acid derivatives as human neutrophil elastase (hNE) inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-020-02684-4
Abstract: Herein we report our investigation concerning the development of Human neutrophil elastase (hNE) inhibitors for the treatment of Acute Respiratory Distress Syndrome (ARDS). Various benzenesulfonic acid derived compounds were synthesized and evaluated as competitive inhibitors… read more here.
Keywords: benzenesulfonic acid; neutrophil elastase; human neutrophil; hne ... See more keywords
Significant elevation of salivary human neutrophil peptides 1-3 levels by probiotic milk in preschool children with severe early childhood caries: a randomized controlled trial.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical oral investigations"
DOI: 10.1007/s00784-020-03606-9
Abstract: OBJECTIVES To determine salivary human neutrophil peptides 1-3 (HNP1-3) levels in caries-free preschool children and in those with early childhood caries (ECC) or severe-ECC, in a daily probiotic group, receiving reconstituted milk with the probiotic… read more here.
Keywords: milk; hnp1; hnp1 levels; salivary human ... See more keywords
Neutralization of Pseudomonas auruginosa Exotoxin A by human neutrophil peptide 1.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.05.011
Abstract: Pseudomonas aeruginosa produces a large number of virulence factors, including the extracellular protein, Exotoxin A (ETA). Human Neutrophil Peptide 1 (HNP1) neutralizes the Exotoxin A. HNP1 belongs to the family of α-defensins, small effector peptides… read more here.
Keywords: auruginosa exotoxin; pseudomonas auruginosa; human neutrophil; neutrophil peptide ... See more keywords
Engineering Molecular Probes for In Vivo Near-Infrared Fluorescence/Photoacoustic Duplex Imaging of Human Neutrophil Elastase.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c04891
Abstract: Early detection of human neutrophil elastase (HNE), the potential biomarker of lung cancer, is crucial for the accurate diagnosis and evaluation of lung cancer. Currently, little progress of HNE-activated probes has been made for in… read more here.
Keywords: duplex imaging; near infrared; neutrophil elastase; infrared fluorescence ... See more keywords
Human neutrophil peptides 1-3 protect the murine urinary tract from uropathogenic Escherichia coli challenge
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2206515119
Abstract: Significance Genetic variations can affect the immune response to infectious conditions. Recent evidence shows DNA copy number variations (CNVs) in the DEFA1A3 locus, which encodes for human neutrophil peptides 1-3 (HNP1-3) are associated with urinary… read more here.
Keywords: urinary tract; uropathogenic escherichia; tract; escherichia coli ... See more keywords
Identification of novel human neutrophil elastase inhibitors from dietary phytochemicals using in silico and in vitro studies
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1847685
Abstract: Abstract Human neutrophil elastase (HNE) has been well studied as a therapeutic target for inflammatory diseases for several decades. A variety of small-molecule HNE inhibitors have been well known, and their mode of binding at… read more here.
Keywords: hne; dietary phytochemicals; human neutrophil; identification novel ... See more keywords
Distinctive Roles and Mechanisms of Human Neutrophil Peptides in Experimental Sepsis and Acute Respiratory Distress Syndrome
Sign Up to like & getrecommendations! Published in 2018 at "Critical Care Medicine"
DOI: 10.1097/ccm.0000000000003265
Abstract: Objectives: To examine the effects and mechanisms of human neutrophil peptides in systemic infection and noninfectious inflammatory lung injury. Design: Prospective experimental study. Setting: University hospital-based research laboratory. Subjects: In vitro human cells and in… read more here.
Keywords: sepsis; neutrophil peptides; human neutrophil; injury ... See more keywords
Genotype frequencies of human neutrophil antigen‐3 in the Chinese Zhuang and Dong populations
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Immunogenetics"
DOI: 10.1111/iji.12339
Abstract: Individuals with the human neutrophil antigen (HNA)‐3b/3b type can produce HNA‐3a antibodies, which have been reported to cause severe, sometimes fatal transfusion‐related acute lung injury (TRALI). Our study aimed to determine the genotype frequency of… read more here.
Keywords: hna genotype; genotype frequencies; neutrophil antigen; zhuang ... See more keywords