CD200R1L is a functional evolutionary conserved activating receptor in human neutrophils
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DOI: 10.1002/jlb.2a0520-334r
Abstract: Inhibitory and activating immune receptors play a key role in modulating the amplitude and duration of immune responses during infection and in maintaining immune balance in homeostatic conditions. The CD200 Receptor (CD200R) gene family in… read more here.
Keywords: activating receptor; receptor human; receptor; human neutrophils ... See more keywords
Allosteric targeting of the FFA2 receptor (GPR43) restores responsiveness of desensitized human neutrophils
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DOI: 10.1002/jlb.2a0720-432r
Abstract: The G protein‐coupled free fatty acid receptor 2 (FFA2R) is highly expressed on neutrophils and was previously described to regulate neutrophil activation. Allosteric targeting of G protein‐coupled receptors (GPCRs) is increasingly explored to create distinct… read more here.
Keywords: activation; receptor; allosteric targeting; human neutrophils ... See more keywords
Effect of extracellular vesicles from S. aureus‐challenged human neutrophils on macrophages
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DOI: 10.1002/jlb.3ab0320-156r
Abstract: Staphylococcus aureus enhances neutrophil extracellular vesicle (EV) production. To investigate whether S. aureus viability influences EV biogenesis, EVs were isolated from human neutrophils incubated with viable bacteria (bEVs) or heat‐killed bacteria (heat‐killed EVs). Protein analysis,… read more here.
Keywords: dna; heat killed; production; human neutrophils ... See more keywords
Human neutrophils activated by TLR8 agonists, with or without IFNγ, synthesize and release EBI3, but not IL‐12, IL‐27, IL‐35, or IL‐39
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3ma0520-054r
Abstract: The IL‐12 family of cytokines plays crucial functions in innate and adaptive immunity. These cytokines include heterodimers sharing distinct α (IL‐12A, IL‐23A, and IL‐27A) with two β (IL‐12B and Epstein‐Barr virus induced gene 3 [EBI3])… read more here.
Keywords: neutrophils incubated; tlr8 agonists; neutrophils activated; human neutrophils ... See more keywords
Prolonged exposure to hypoxia induces an autophagy‐like cell survival program in human neutrophils
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DOI: 10.1002/jlb.4a0319-079rr
Abstract: Neutrophils contribute to low oxygen availability at inflammatory sites through the generation of reactive oxidants. They are also functionally affected by hypoxia, which delays neutrophil apoptosis. However, the eventual fate of neutrophils in hypoxic conditions… read more here.
Keywords: hypoxia; autophagy like; human neutrophils; cell ... See more keywords
A GRIM fate for human neutrophils in airway disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.5ce0418-162r
Abstract: Nowhere in biomedical research does a cell type seem as simultaneously vital and vexing as the neutrophil. Human immunity deteriorates rapidly in the absence of neutrophils whereas their dysfunctional abundance can cause misery and harm,… read more here.
Keywords: airway disease; sputum; drug; human neutrophils ... See more keywords
Endocytosis is required for exocytosis and priming of respiratory burst activity in human neutrophils
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DOI: 10.1007/s00011-017-1070-2
Abstract: Objective and designNeutrophil generation of reactive oxygen species (ROS) is enhanced by exposure to pro-inflammatory agents in a process termed priming. Priming is depending on exocytosis of neutrophil granules and p47phox phosphorylation-dependent translocation of cytosolic… read more here.
Keywords: priming respiratory; endocytosis; human neutrophils; exocytosis ... See more keywords
Evaluation of In Vitro Immunomodulatory Activity of Withania somnifera Roots on Human Neutrophils
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DOI: 10.1007/s12010-021-03518-8
Abstract: The present study encompasses in vitro immunomodulatory activity of Withania somnifera WS (Solanaceae) examined on human neutrophils. The isolated compound of Withania somnifera roots was screened for its possible immunomodulatory activity by nitro blue tetrazolium… read more here.
Keywords: immunomodulatory activity; withania somnifera; activity; human neutrophils ... See more keywords
Effects of recombinant human lactoferrin on calcium signaling and functional responses of human neutrophils.
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DOI: 10.1016/j.abb.2019.108122
Abstract: Lactoferrin is a non-heme iron-binding glycoprotein with multiple health-beneficial functions including antimicrobial, antioxidant, anticarcinogenic, and immunomodulatory effects. There is emerging evidence that neutrophils may serve as targets of lactoferrin in vivo, and here we show… read more here.
Keywords: recombinant human; lactoferrin; human lactoferrin; human neutrophils ... See more keywords
Human neutrophils degrade methacrylate resin composites and tooth dentin.
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DOI: 10.1016/j.actbio.2019.02.033
Abstract: Cholesterol esterase-like (CE) activity from saliva and esterase from cariogenic bacteria hydrolyze ester linkages of dental methacrylate resins. Collagenolytic, matrix metalloproteinase-like (MMP) activities from dentin and bacteria degrade collagen in demineralized tooth dentin. Human neutrophils… read more here.
Keywords: resin; tooth dentin; mmp activities; mmp ... See more keywords
Design and synthesis of β-carboline and combretastatin derivatives as anti-neutrophilic inflammatory agents.
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DOI: 10.1016/j.bioorg.2021.104846
Abstract: A series of β-carboline derivatives was synthesized by the Pictet-Spengler reaction with or without the combretastatin skeleton. The structures of these derivatives were elucidated by spectroscopic techniques. All synthesized compounds were evaluated for their anti-inflammatory… read more here.
Keywords: design synthesis; ntu 228; carboline combretastatin; synthesis carboline ... See more keywords