Competitive docking model for prediction of the human nicotinic acetylcholine receptor α7 binding of tobacco constituents
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DOI: 10.18632/oncotarget.24458
Abstract: The detrimental health effects associated with tobacco use constitute a major public health concern. The addiction associated with nicotine found in tobacco products has led to difficulty in quitting among users. Nicotinic acetylcholine receptors (nAChRs)… read more here.
Keywords: tobacco; human nicotinic; nicotinic acetylcholine; model ... See more keywords
Comparative Assessment of Outcomes in Drug Treatment for Smoking Cessation and Role of Genetic Polymorphisms of Human Nicotinic Acetylcholine Receptor Subunits
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DOI: 10.3389/fgene.2022.812715
Abstract: Objective: To investigate the effects of genetic polymorphisms of human nicotinic acetylcholine receptor subunits α3, α4 and α5, which are encoded by CHRNA3, CHRNA4 CHRNA5 genes, respectively, on nicotine addiction and outcomes of pharmacological treatments… read more here.
Keywords: nicotinic acetylcholine; acetylcholine receptor; treatment; smoking cessation ... See more keywords
Single-Disulfide Conopeptide Czon1107, an Allosteric Antagonist of the Human α3β4 Nicotinic Acetylcholine Receptor
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DOI: 10.3390/md20080497
Abstract: Conopeptides are peptides in the venom of marine cone snails that are used for capturing prey or as a defense against predators. A new cysteine-poor conopeptide, Czon1107, has exhibited non-competitive inhibition with an undefined allosteric… read more here.
Keywords: czon1107; human nicotinic; conopeptide czon1107; nicotinic acetylcholine ... See more keywords