High amplitude and low frequency cyclic mechanical strain promotes degeneration of human nucleus pulposus cells via the NF‐κB p65 pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26551
Abstract: Disc degeneration alters the structure and function of intervertebral discs and is the basis of spinal degenerative diseases. To establish the molecular mechanism of intervertebral disc degeneration caused by mechanical strain, this study examined the… read more here.
Keywords: human nucleus; cms; pulposus cells; pulposus ... See more keywords
Regenerative Capability of Human Nucleus Pulposus Cells in Degenerated Disc Under Hydrostatic Pressure Mimicking Physiologically Relevant Intradiscal Pressure In Vitro
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DOI: 10.1097/brs.0000000000004530
Abstract: Study Design. Isolated human nucleus pulposus (hNP) cells from the degenerated intervertebral disc (IVD) were incubated under hydrostatic pressure (HP) and evaluated for regenerative potential. Objectives. To characterize metabolic turnover in hNP cells isolated from… read more here.
Keywords: human nucleus; pulposus cells; pressure; nucleus pulposus ... See more keywords
Relationships Between Disc Degeneration and Autophagy Expression in Human Nucleus Pulposus
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DOI: 10.1111/os.12573
Abstract: To elaborate on the relationship between degeneration grade and autophagy expression in human nucleus pulposus obtained from surgical procedures. read more here.
Keywords: human nucleus; nucleus pulposus; expression human; autophagy expression ... See more keywords