Role of caveolin-1 in human organ function and disease: friend or foe?
Sign Up to like & getrecommendations! Published in 2021 at "Carcinogenesis"
DOI: 10.1093/carcin/bgab080
Abstract: Caveolin-1 (Cav-1) is a structural protein component of caveolae, which are invaginations of the plasma membrane involved in various cellular processes, including endocytosis, extracellular matrix organization, cholesterol distribution, cell migration, and signaling. Mounting evidence over… read more here.
Keywords: caveolin human; caveolin; role caveolin; role ... See more keywords
Successful Implementation of Unmanned Aircraft Use for Delivery of a Human Organ for Transplantation
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Surgery"
DOI: 10.1097/sla.0000000000003630
Abstract: Objective: To understand and overcome the challenges associated with moving life-urgent payloads using unmanned aircraft. Background Data: Organ transportation has not been substantially innovated in the last 60 years. Unmanned aircraft systems (UAS; ie, drones)… read more here.
Keywords: unmanned aircraft; aircraft; human organ; transplantation ... See more keywords
Human organ rejuvenation by VEGF-A: Lessons from the skin
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm6756
Abstract: Transplanting aged human skin onto young SCID/beige mice morphologically rejuvenates the xenotransplants. This is accompanied by angiogenesis, epidermal repigmentation, and substantial improvements in key aging-associated biomarkers, including ß-galactosidase, p16ink4a, SIRT1, PGC1α, collagen 17A, and MMP1.… read more here.
Keywords: skin; vegf; human skin; rejuvenation ... See more keywords
Developing pig-to-human organ transplants
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abo7935
Abstract: Recent advances raise hope for a promising solution to the transplant organ shortage Over 100,000 people in the US are currently waiting for organ transplants. Because the human organ donor pool cannot keep pace with… read more here.
Keywords: organ transplants; pig human; physiology; developing pig ... See more keywords
Testing the delivery of human organ transportation with drones in the real world
Sign Up to like & getrecommendations! Published in 2022 at "Science Robotics"
DOI: 10.1126/scirobotics.adf5798
Abstract: Last-mile transportation of human donor lungs in a densely populated urban environment has been made possible with drones. Description Last-mile transportation of human donor lungs in a densely populated urban environment has been made possible… read more here.
Keywords: transportation drones; delivery human; organ transportation; transportation ... See more keywords
In-silico performance, validation, and modeling of the Nanostring Banff Human Organ transplant gene panel using archival data from human kidney transplants
Sign Up to like & getrecommendations! Published in 2021 at "BMC Medical Genomics"
DOI: 10.1186/s12920-021-00891-5
Abstract: Background RNA gene expression of renal transplantation biopsies is commonly used to identify the immunological patterns of graft rejection. Mostly done with microarrays, seminal findings defined the patterns of gene sets associated with rejection and… read more here.
Keywords: gene expression; banff human; human organ; panel ... See more keywords
Human Organ-on-a-Chip Microphysiological Systems to Model Musculoskeletal Pathologies and Accelerate Therapeutic Discovery
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.846230
Abstract: Human Microphysiological Systems (hMPS), otherwise known as organ- and tissue-on-a-chip models, are an emerging technology with the potential to replace in vivo animal studies with in vitro models that emulate human physiology at basic levels.… read more here.
Keywords: therapeutic discovery; musculoskeletal tissues; chip; microphysiological systems ... See more keywords