Human Organoids and Organs‐on‐Chips for Addressing COVID‐19 Challenges
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105187
Abstract: Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), poses an imminent threat to our lives. Although animal models and monolayer cell cultures are utilized for pathogenesis studies and the development… read more here.
Keywords: organoids organs; human organoids; organs chips; covid ... See more keywords
3D printed human organoids: High throughput system for drug screening and testing in current COVID‐19 pandemic
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28166
Abstract: In the current pandemic, scenario the world is facing a huge shortage of effective drugs and other prophylactic medicine to treat patients which created havoc in several countries with poor resources. With limited demand and… read more here.
Keywords: drug screening; human organoids; printed human; screening testing ... See more keywords
Advances in development and application of human organoids
Sign Up to like & getrecommendations! Published in 2021 at "3 Biotech"
DOI: 10.1007/s13205-021-02815-7
Abstract: Innumerable studies associated with cellular differentiation, tissue response and disease modeling have been conducted in two-dimensional (2D) culture systems or animal models. This has been invaluable in deciphering the normal and disease states in cell… read more here.
Keywords: development application; advances development; physiology; human organoids ... See more keywords
Towards manufacturing of human organoids.
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology advances"
DOI: 10.1016/j.biotechadv.2019.107460
Abstract: Organoids are 3D miniature versions of organs produced from stem cells derived from either patient or healthy individuals in vitro that recapitulate the actual organ. Organoid technology has ensured an alternative to pre-clinical drug testing… read more here.
Keywords: medicine; human organoids; manufacturing human; towards manufacturing ... See more keywords
The Organoid Cell Atlas
Sign Up to like & getrecommendations! Published in 2020 at "Nature Biotechnology"
DOI: 10.1038/s41587-020-00762-x
Abstract: To the Editor — Human organoids hold tremendous potential for biomedical applications1–3 (Fig. 1a,b). These three-dimensional structures of cultured cells recapitulate important aspects of in vivo organ development and biological function. They provide tractable in… read more here.
Keywords: single cell; cell atlas; biology; human organoids ... See more keywords
Efficient and error-free fluorescent gene tagging in human organoids without double-strand DNA cleavage
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Biology"
DOI: 10.1371/journal.pbio.3001527
Abstract: CRISPR-associated nucleases are powerful tools for precise genome editing of model systems, including human organoids. Current methods describing fluorescent gene tagging in organoids rely on the generation of DNA double-strand breaks (DSBs) to stimulate homology-directed… read more here.
Keywords: gene tagging; fluorescent gene; human organoids; double strand ... See more keywords
3D Human Organoids: The Next “Viral” Model for the Molecular Basis of Infectious Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10071541
Abstract: The COVID-19 pandemic has driven the scientific community to adopt an efficient and reliable model that could keep up with the infectious disease arms race. Coinciding with the pandemic, three dimensional (3D) human organoids technology… read more here.
Keywords: infectious diseases; human organoids; organoids next; next viral ... See more keywords
Human Organoids as a Promising Platform for Fighting COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.64993
Abstract: The coronavirus disease 2019 (COVID-19) global pandemic evoked by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered a major public health problem with significant morbidity and mortality. Understanding the pathogenesis and molecular mechanisms… read more here.
Keywords: platform; human organoids; platform fighting; promising platform ... See more keywords