Activation of TNF‐α/NF‐κB axis enhances CRL4BDCAF 11 E3 ligase activity and regulates cell cycle progression in human osteosarcoma cells
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12176
Abstract: Cullin 4B, a member of the Cullins, which serve as scaffolds to facilitate the assembly of E3 ligase complexes, is aberrantly expressed in many cancers, including osteosarcoma. Recently, we observed that CUL4B forms the CRL4BDCAF11… read more here.
Keywords: ligase; osteosarcoma; tnf axis; osteosarcoma cells ... See more keywords
DEPDC1 as a crucial factor in the progression of human osteosarcoma
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DOI: 10.1002/cam4.5340
Abstract: Novel therapeutic strategies are emerging with the increased understanding of the underlying mechanisms of human osteosarcoma. This current study tends to decipher the potentially critical role of DEP domain‐containing 1 (DEPDC1), a tumor‐related gene, during… read more here.
Keywords: crucial factor; osteosarcoma; factor progression; human osteosarcoma ... See more keywords
Downregulation of microRNA‐15a‐3p is correlated with clinical outcome and negatively regulates cancer proliferation and migration in human osteosarcoma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26294
Abstract: In this study, we investigated the expression, correlation to clinical outcomes and biological functions of microRNA‐15a‐3p (miR‐15a‐3p) in human osteosarcoma. MiR‐15a‐3p expressions in osteosarcoma cell lines and clinical tissues of osteosarcoma patients were measured by… read more here.
Keywords: proliferation migration; mir 15a; osteosarcoma; cancer ... See more keywords
7‐hydroxy‐staurosporine, UCN‐01, induces DNA damage response, and autophagy in human osteosarcoma U2‐OS cells
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DOI: 10.1002/jcb.26652
Abstract: Human osteosarcoma (bone cancer) is a highly malignant and the most prevalent bone tumor affecting children. Despite recent advances in the understanding of the molecular mechanism by which anticancer drugs kill osteosarcoma or block its… read more here.
Keywords: damage response; dna damage; human osteosarcoma; osteosarcoma cells ... See more keywords
Preparation of adriamycin gelatin microsphere‐loaded decellularized periosteum that is cytotoxic to human osteosarcoma cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27753
Abstract: The purpose of this study was to develop a novel approach to treat bone osteosarcoma using a multipurpose scaffold aiming for local drug delivery. The slowly releasing microspheres was designed to deliver the chemotherapy drug… read more here.
Keywords: decellularized periosteum; osteosarcoma cells; periosteum; human osteosarcoma ... See more keywords
Doxorubicin induces ZAKα overexpression with a subsequent enhancement of apoptosis and attenuation of survivability in human osteosarcoma cells
Sign Up to like & getrecommendations! Published in 2018 at "Environmental Toxicology"
DOI: 10.1002/tox.22507
Abstract: Human osteosarcoma (OS) is a malignant cancer of the bone. It exhibits a characteristic malignant osteoblastic transformation and produces a diseased osteoid. A previous study demonstrated that doxorubicin (DOX) chemotherapy decreases human OS cell proliferation… read more here.
Keywords: apoptosis; effect; human osteosarcoma; zak overexpression ... See more keywords
Reduction of invasion and cell stemness and induction of apoptotic cell death by Cinnamomum cassia extracts on human osteosarcoma cells
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DOI: 10.1002/tox.23481
Abstract: Cinnamomum cassia possesses antioxidative activity and induces the apoptotic properties of various cancer types. However, its effect on osteosarcoma invasion and cancer stemness remains ambiguous. Here, we examined the molecular evidence of the anti‐invasive effects… read more here.
Keywords: cell; cinnamomum cassia; human osteosarcoma; 143b cells ... See more keywords
Baicalin induces apoptosis in human osteosarcoma cell through ROS-mediated mitochondrial pathway
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DOI: 10.1080/14786419.2017.1359173
Abstract: Abstract Baicalin is extracted from a traditional Chinese herb, Scutellaria baicalensis. In this study, the anticancer activity and underlying mechanisms of baicalin towards human osteosarcoma cell (HOS) were investigated. Baicalin could inhibit HOS cell proliferation… read more here.
Keywords: baicalin; osteosarcoma cell; apoptosis human; cell ... See more keywords
Antitumor effect of focal adhesion kinase inhibitor PF562271 against human osteosarcoma in vitro and in vivo
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DOI: 10.1111/cas.13256
Abstract: Focal adhesion kinase (FAK) overexpression is related to invasive and metastatic properties in different kinds of cancers. Target therapy by inhibiting FAK has achieved promising effect in some cancer treatments, but its effect in human… read more here.
Keywords: inhibitor; kinase; osteosarcoma; effect ... See more keywords
Andrographolide Induces Autophagic Cell Death and Inhibits Invasion and Metastasis of Human Osteosarcoma Cells in An Autophagy-Dependent Manner
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DOI: 10.1159/000485536
Abstract: Background/Aims: Osteosarcoma (OS) is the most common primary malignant tumor of bone tissue. Although treatment effectiveness has improved, the OS survival rate has fluctuated in recent years. Andrographolide (AG) has been reported to have antitumor… read more here.
Keywords: death; osteosarcoma cells; cell death; invasion metastasis ... See more keywords
Anti-proliferative, pro-apoptotic and anti-invasive effect of EC/EV system in human osteosarcoma
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DOI: 10.18632/oncotarget.17089
Abstract: Osteosarcoma is the most common and aggressive bone tumor in children. The Endocannabinoid/Endovanilloid system has been proposed as anticancer target in tumor of different origins. This system is composed of two receptors (CB1 and CB2),… read more here.
Keywords: anti proliferative; system; osteosarcoma; effect ... See more keywords