N-terminal tagging of human P2X7 receptor disturbs calcium influx and dye uptake
Sign Up to like & getrecommendations! Published in 2017 at "Purinergic Signalling"
DOI: 10.1007/s11302-017-9598-8
Abstract: The P2X7 receptor is a frequently studied member of the purinergic receptor family signalling via channel opening and membrane pore formation. Fluorescent imaging is an important molecular method for studying cellular receptor expression and localization.… read more here.
Keywords: human p2x7; channel opening; receptor; p2x7 receptor ... See more keywords
Identification of a novel P2X7 antagonist using structure-based virtual screening
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1094607
Abstract: P2X4 and P2X7 receptors are ATP-gated ion channels, which play important roles in neuropathic and inflammatory pain, and as such they are important drug targets in diseases of inflammatory origin. While several compounds targeting P2X4… read more here.
Keywords: human p2x7; using structure; p2x7; p2x4 ... See more keywords